Preferred Label : Beta-2 Adrenergic Receptor;
NCIt synonyms : B2AR; ADRB2; Beta-2 Adrenoceptor; Beta-2-Adrenergic Receptor; BAR; Beta-Adrenergic Receptor; ADRB2R; ADRBR; Adrenergic, Beta-2-, Receptor, Surface; Catecholamine Receptor;
NCIt definition : Beta-2 adrenergic receptor (413 aa, 47 kDa) is encoded by the human ADRB2 gene. This
protein is involved in both catecholamine binding and G protein-coupled receptor signaling.;
NCIt note : Encoded by human ADRB2 Gene (GPCR Family), Beta-2 Adrenergic Receptor directly associates
with one of its effectors, class C L-type calcium channel Ca(V)1.2. This receptor-channel
complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and
the counterbalancing phosphatase, PP2A. This signaling complex assembly ensures specific
and rapid signaling by this G protein-coupled receptor that stimulates adenylyl cyclase
activity. (LocusLink);
Origin ID : C21297;
UMLS CUI : C2976741;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_affected_by_chemical_or_drug
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
