Endocytosis Pathway

Preferred Label : Endocytosis Pathway;

NCIt related terms : Endocytosis;

Alternative definition : KEGG: Endocytosis is a mechanism for cells to remove ligands, nutrients, plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.;

KEGG ID : hsa04144;

Details

Origin ID

C91473;

UMLS CUI

C2984285;

Automatic exact mappings (from CISMeF team)
- Endocytosis [PASCAL theme]
- endocytosis [MeSH Descriptor]
- endocytosis [MeSH concept]
- endocytosis [GO term]
- endocytosis [IUPAC Term]
- endocytosis [COVID-19 Thesaurus concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- ADP-Ribosylation Factor 1 [NCIt concept]
- ADP-Ribosylation Factor GTPase-Activating Protein 3 [NCIt concept]
- AP-2 Complex Subunit Beta [NCIt concept]
- ARF GTPase-Activating Protein GIT1 [NCIt concept]
- ARF GTPase-Activating Protein GIT2 [NCIt concept]
- Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain-Containing 1 [NCIt concept]
- Auxilin [NCIt concept]
- Beta-1 Adrenergic Receptor [NCIt concept]
- Beta-2 Adrenergic Receptor [NCIt concept]
- Beta-3 Adrenergic Receptor [NCIt concept]
- Beta-Adrenergic Receptor Kinase 1 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 2 [NCIt concept]
- Beta-Arrestin-1 [NCIt concept]
- Beta-Arrestin-2 [NCIt concept]
- C-C Chemokine Receptor Type 5 [NCIt concept]
- C-C Chemokine Receptor Type 6 [NCIt concept]
- C-C Chemokine Receptor Type 7 [NCIt concept]
- C-X-C Chemokine Receptor Type 1 [NCIt concept]
- C-X-C Chemokine Receptor Type 2 [NCIt concept]
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- Caveolin-1 [NCIt concept]
- Caveolin-2 [NCIt concept]
- Caveolin-3 [NCIt concept]
- Charged Multivesicular Body Protein 2a [NCIt concept]
- Charged Multivesicular Body Protein 2b [NCIt concept]
- Charged Multivesicular Body Protein 7 [NCIt concept]
- Clathrin Heavy Chain 1 [NCIt concept]
- Clathrin Heavy Chain 2 [NCIt concept]
- Cytokine Receptor Common Subunit Gamma [NCIt concept]
- Dynamin-1 [NCIt concept]
- Dynamin-2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- EH Domain-Containing Protein 1 [NCIt concept]
- Endophilin-A2 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Epidermal Growth Factor Receptor Pathway Substrate 15 [NCIt concept]
- Epidermal Growth Factor Receptor Substrate 15-Like 1 [NCIt concept]
- F-Actin-Capping Protein Subunit Alpha-2 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 Isoform IIIb [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Fibroblast Growth Factor Receptor 4 [NCIt concept]
- Folate Receptor Alpha [NCIt concept]
- Folate Receptor Beta [NCIt concept]
- G Protein-Coupled Receptor Kinase 4 [NCIt concept]
- G Protein-Coupled Receptor Kinase 5 [NCIt concept]
- G Protein-Coupled Receptor Kinase 6 [NCIt concept]
- G Protein-Coupled Receptor Kinase 7 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase Nras [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain E [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain F [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain G [NCIt concept]
- Heat Shock 70 kDa Protein 1A/1B [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 1 [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 2 [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Interleukin-2 Receptor Subunit Alpha [NCIt concept]
- Interleukin-2 Receptor Subunit Beta [NCIt concept]
- Kinesin Heavy Chain Isoform 5A [NCIt concept]
- Kinesin-1 Heavy Chain [NCIt concept]
- Low Density Lipoprotein Receptor Adapter Protein 1 [NCIt concept]
- Low-Density Lipoprotein Receptor [NCIt concept]
- MYC Box-Dependent-Interacting Protein 1 [NCIt concept]
- Macrophage Colony-Stimulating Factor 1 Receptor [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 [NCIt concept]
- Partitioning Defective 3 Homolog [NCIt concept]
- Partitioning Defective 6 Homolog Alpha [NCIt concept]
- Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Alpha [NCIt concept]
- Protease-Activated Receptor 1 [NCIt concept]
- Protein Kinase C Iota Type [NCIt concept]
- Protein PML [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Rab GTPase-Binding Effector Protein 1 [NCIt concept]
- Ras-Related Protein Rab-5A [NCIt concept]
- Ras-Related Protein Rab-5B [NCIt concept]
- Ras-Related Protein Rab-5C [NCIt concept]
- Ras-Related Protein Rab-7a [NCIt concept]
- Ras-Related Protein Rab-8A [NCIt concept]
- SH3 Domain-Containing Kinase-Binding Protein 1 [NCIt concept]
- STAM-Binding Protein [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transferrin Receptor Protein 1 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Susceptibility Gene 101 Protein [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 8 [NCIt concept]
- Vacuolar Protein Sorting-Associated Protein 35 [NCIt concept]
- Vacuolar Protein Sorting-Associated Protein 45 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- WAS/WASL-Interacting Protein Family Member 1 [NCIt concept]
- Zinc Finger FYVE Domain-Containing Protein 9 [NCIt concept]
pathway_has_gene_element
- ADRB1 wt Allele [NCIt concept]
- ADRB2 wt Allele [NCIt concept]
- ADRB3 wt Allele [NCIt concept]
- AP2B1 wt Allele [NCIt concept]
- ARF1 wt Allele [NCIt concept]
- ARF6 wt Allele [NCIt concept]
- ARFGAP3 wt Allele [NCIt concept]
- ARRB1 wt Allele [NCIt concept]
- ARRB2 wt Allele [NCIt concept]
- ASAP1 wt Allele [NCIt concept]
- BIN1 wt Allele [NCIt concept]
- CAPZA2 wt Allele [NCIt concept]
- CAV1 wt Allele [NCIt concept]
- CAV2 wt Allele [NCIt concept]
- CAV3 wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CCR5 wt Allele [NCIt concept]
- CCR6 wt Allele [NCIt concept]
- CCR7 wt Allele [NCIt concept]
- CHMP2A wt Allele [NCIt concept]
- CHMP2B wt Allele [NCIt concept]
- CHMP7 wt Allele [NCIt concept]
- CLTC wt Allele [NCIt concept]
- CLTCL1 wt Allele [NCIt concept]
- CSF1R wt Allele [NCIt concept]
- CXCR1 wt Allele [NCIt concept]
- CXCR2 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- DNAJC6 wt Allele [NCIt concept]
- DNM1 wt Allele [NCIt concept]
- DNM2 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- EHD1 wt Allele [NCIt concept]
- EPS15 wt Allele [NCIt concept]
- EPS15L1 wt Allele [NCIt concept]
- F2R wt Allele [NCIt concept]
- FGFR2 wt Allele [NCIt concept]
- FGFR3 wt Allele [NCIt concept]
- FGFR4 wt Allele [NCIt concept]
- FLT1 wt Allele [NCIt concept]
- FOLR1 wt Allele [NCIt concept]
- FOLR2 wt Allele [NCIt concept]
- GIT1 wt Allele [NCIt concept]
- GIT2 wt Allele [NCIt concept]
- GRK2 wt Allele [NCIt concept]
- GRK3 wt Allele [NCIt concept]
- GRK4 wt Allele [NCIt concept]
- GRK5 wt Allele [NCIt concept]
- GRK6 wt Allele [NCIt concept]
- GRK7 wt Allele [NCIt concept]
- HGS wt Allele [NCIt concept]
- HLA-E wt Allele [NCIt concept]
- HLA-F wt Allele [NCIt concept]
- HLA-G wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- HSPA1A wt Allele [NCIt concept]
- HSPA1B wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- IL2RA wt Allele [NCIt concept]
- IL2RB wt Allele [NCIt concept]
- IL2RG wt Allele [NCIt concept]
- IQSEC1 wt Allele [NCIt concept]
- IQSEC2 wt Allele [NCIt concept]
- ITCH wt Allele [NCIt concept]
- KDR wt Allele [NCIt concept]
- KIF5A wt Allele [NCIt concept]
- KIF5B wt Allele [NCIt concept]
- LDLR wt Allele [NCIt concept]
- LDLRAP1 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NTRK1 wt Allele [NCIt concept]
- PARD3 wt Allele [NCIt concept]
- PARD6A wt Allele [NCIt concept]
- PIP5K1A wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PML wt Allele [NCIt concept]
- PRKCI wt Allele [NCIt concept]
- RAB35 wt Allele [NCIt concept]
- RAB5A wt Allele [NCIt concept]
- RAB5B wt Allele [NCIt concept]
- RAB5C wt Allele [NCIt concept]
- RAB7A wt Allele [NCIt concept]
- RAB8A wt Allele [NCIt concept]
- RABEP1 wt Allele [NCIt concept]
- RET wt Allele [NCIt concept]
- SH3GL1 wt Allele [NCIt concept]
- SH3KBP1 wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- STAMBP wt Allele [NCIt concept]
- TFRC wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TSG101 wt Allele [NCIt concept]
- USP8 wt Allele [NCIt concept]
- VPS35 wt Allele [NCIt concept]
- VPS45 wt Allele [NCIt concept]
- WIPF1 wt Allele [NCIt concept]
- WWP1 wt Allele [NCIt concept]
- ZFYVE9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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