Macrophage Colony-Stimulating Factor 1 Receptor

Preferred Label : Macrophage Colony-Stimulating Factor 1 Receptor;

NCIt synonyms : C-FMS; CSF1R Gene Product; CD115; CSF1R; CSF-1-R; Colony Stimulating Factor 1 Receptor; c-FMS Protein; Proto-Oncogene c-Fms; CSF-1 Receptor; Macrophage Colony Stimulating Factor I Receptor; CD115 Antigen; CSF-1R; M-CSF-R; EC 2.7.10.1; Colony Stimulating Factor-1 Receptor;

NCIt definition : Macrophage colony-stimulating factor 1 receptor (972 aa, 108 kDa) is encoded by the human CSF1R gene. This protein plays a role in protein phosphorylation, macrophage differentiation, and the regulation of cell proliferation.;

Details

Origin ID

C17392;

UMLS CUI

C4082532;

OMIM relation
- Colony-stimulating factor 1 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CSF1R Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- CSF1R NP_005202.2:p.H362R [NCIt concept]
- CSF1R NP_005202.2:p.N648S [NCIt concept]
- CSF1R Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Colony Stimulating Factor Signaling Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Anti-CSF1R Monoclonal Antibody AMB-05X [NCIt concept]
- Anti-CSF1R Monoclonal Antibody IMC-CS4 [NCIt concept]
- Axatilimab [NCIt concept]
- CSF-1R/DDR1/VEGFR2 Inhibitor C019199 [NCIt concept]
- CSF1R Inhibitor HMPL-653 [NCIt concept]
- CSF1R Inhibitor PLX73086 [NCIt concept]
- Cabiralizumab [NCIt concept]
- Dovitinib [NCIt concept]
- Edicotinib [NCIt concept]
- Elzovantinib [NCIt concept]
- Emactuzumab [NCIt concept]
- FLT3/KIT/CSF1R Inhibitor NMS-03592088 [NCIt concept]
- Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate [NCIt concept]
- Nintedanib [NCIt concept]
- Nintedanib Esylate [NCIt concept]
- Pexidartinib [NCIt concept]
- Pexidartinib Hydrochloride [NCIt concept]
- Pimicotinib [NCIt concept]
- Quizartinib [NCIt concept]
- Quizartinib Dihydrochloride [NCIt concept]
- Segigratinib [NCIt concept]
- Sotuletinib [NCIt concept]
- Vimseltinib [NCIt concept]
- cFMS Tyrosine Kinase Inhibitor ARRY-382 [NCIt concept]

Keyword's position in hierarchy(ies) :

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