Preferred Label : Nintedanib Esylate;
NCIt synonyms : Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Ethanesulfonate; Nintedanib Ethanesulfonate;
NCIt definition : The esylate salt form of nintedanib, an orally bioavailable, indolinone-derived inhibitor
of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs),
with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration,
nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor
(VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor
receptor (PDGFR), and colony stimulating factor 1 receptor (CSF1R) tyrosine kinases,
which may result in the induction of endothelial cell apoptosis, the reduction in
tumor vasculature, the inhibition of tumor cell proliferation and migration, and antifibrotic
activity in pulmonary fibrosis. In addition, nintedanib also binds to and inhibits
members of the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like
tyrosine kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor
angiogenesis, tumor cell proliferation and metastasis, as well as pulmonary fibrosis.;
UNII : 42F62RTZ4G;
InChIKey : MMMVNAGRWOJNMW-FJBFXRHMSA-N;
CAS number : 656247-18-6;
Drug name : Ofev;
NCI Metathesaurus CUI : CL555362;
Origin ID : C154570;
UMLS CUI : C3529778;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
