Nintedanib - CISMeF

Preferred Label : Nintedanib;

NCIt synonyms : Multitargeted Tyrosine Kinase Inhibitor BIBF 1120; Intedanib; Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;

NCIt related terms : BIBF 1120; tyrosine kinase inhibitor BIBF 1120;

NCIt definition : An orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and colony stimulating factor 1 receptor (CSF1R) tyrosine kinases, which may result in the induction of endothelial cell apoptosis, the reduction in tumor vasculature, the inhibition of tumor cell proliferation and migration, and antifibrotic activity in pulmonary fibrosis. In addition, nintedanib also binds to and inhibits members of the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like tyrosine kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor angiogenesis, tumor cell proliferation and metastasis, as well as pulmonary fibrosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. BIBF 1120 blocks enzymes needed for cells to grow, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.;

UNII : G6HRD2P839;

InChIKey : XZXHXSATPCNXJR-ZIADKAODSA-N;

CAS number : 656247-17-5;

Drug name : Vargatef;

Molecule name : BIBF-1120; BIBF 1120;

Chemical formula : C31H33N5O4;

Codes from synonyms : CDR0000546734; CDR0000524232; 355;

Details

Origin ID

C62765;

UMLS CUI

C2930789;

Automatic exact mappings (from CISMeF team)
- BIBF 1120 [MeSH concept]
- nintedanib [ATC Code]
Currated CISMeF NLP mapping
- Nintedanib [ICD-11 Extension code]
- Nintedanib [SMS substance]
- Nintedanib (substance) [SNOMED CT concept]
- nintedanib [MeSH concept]
- nintedanib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing nintedanib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nintedanib (substance) [SNOMED CT concept]
- Product containing nintedanib (medicinal product) [SNOMED CT concept]
- nintedanib [MeSH concept]
- nintedanib [ATC Code]
- nintedanib [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Nintedanib Esylate [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor Family [NCIt concept]
- Macrophage Colony-Stimulating Factor 1 Receptor [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
is_free_acid_or_base_form_of
- Nintedanib Esylate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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