Preferred Label : Nintedanib;
NCIt synonyms : Multitargeted Tyrosine Kinase Inhibitor BIBF 1120; Intedanib; Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;
NCIt related terms : BIBF 1120; tyrosine kinase inhibitor BIBF 1120;
NCIt definition : An orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine
kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic,
antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively
binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast
growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and
colony stimulating factor 1 receptor (CSF1R) tyrosine kinases, which may result in
the induction of endothelial cell apoptosis, the reduction in tumor vasculature, the
inhibition of tumor cell proliferation and migration, and antifibrotic activity in
pulmonary fibrosis. In addition, nintedanib also binds to and inhibits members of
the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like tyrosine
kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor angiogenesis,
tumor cell proliferation and metastasis, as well as pulmonary fibrosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. BIBF
1120 blocks enzymes needed for cells to grow, and may prevent the growth of new blood
vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a
type of antiangiogenesis agent.;
UNII : G6HRD2P839;
InChIKey : XZXHXSATPCNXJR-ZIADKAODSA-N;
CAS number : 656247-17-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 656247-17-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Vargatef;
Molecule name : BIBF-1120; BIBF 1120;
Chemical formula : C31H33N5O4;
Codes from synonyms : CDR0000546734; CDR0000524232; 355;
Origin ID : C62765;
UMLS CUI : C2930789;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
