Signal Transduction Inhibition

Preferred Label : Signal Transduction Inhibition;

NCIt definition : Any feature of a cellular signaling process which negatively regulates the further transduction of cell signaling.;

Details

Origin ID

C40821;

UMLS CUI

C1519312;

Automatic exact mappings (from CISMeF team)
- negative regulation of signal transduction [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_involves_gene_product
- Acetylcholinesterase [NCIt concept]
- BMP and Activin Membrane-Bound Inhibitor Homolog [NCIt concept]
- Calcineurin-Binding Protein Cabin-1 [NCIt concept]
- Calreticulin [NCIt concept]
- DEP Domain-Containing mTOR-Interacting Protein [NCIt concept]
- Dickkopf-Related Protein 1 [NCIt concept]
- Dickkopf-Related Protein 2 [NCIt concept]
- Dickkopf-Related Protein 3 [NCIt concept]
- Dickkopf-Related Protein 4 [NCIt concept]
- Dual Specificity Protein Phosphatase 10 [NCIt concept]
- Dual Specificity Protein Phosphatase 4 [NCIt concept]
- Dual Specificity Protein Phosphatase 5 [NCIt concept]
- Dual Specificity Protein Phosphatase 6 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF43 [NCIt concept]
- E3 Ubiquitin-Protein Ligase ZNRF3 [NCIt concept]
- ERBB Receptor Feedback Inhibitor 1 [NCIt concept]
- Follistatin-Related Protein 3 [NCIt concept]
- Hairy/Enhancer-of-Split Related with YRPW Motif Protein 1 [NCIt concept]
- Inner Nuclear Membrane Protein Man1 [NCIt concept]
- Leptin Receptor Overlapping Transcript-Like 1 [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 4 [NCIt concept]
- Menin [NCIt concept]
- Nuclear Receptor Subfamily 1 Group D Member 1 [NCIt concept]
- Profilin-1 [NCIt concept]
- Protein ALEX [NCIt concept]
- Protein Bicaudal C Homolog 1 [NCIt concept]
- Protein KIBRA [NCIt concept]
- Protein Sprouty Homolog 2 [NCIt concept]
- Protein Sprouty Homolog 4 [NCIt concept]
- Ras Association Domain-Containing Protein 7 [NCIt concept]
- Ras GTPase-Activating Protein 2 [NCIt concept]
- Ras GTPase-Activating Protein nGAP [NCIt concept]
- RasGAP-Activating-Like Protein 1 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Epsilon Isoform 2 [NCIt concept]
- Regulator of G-Protein Signaling 22 [NCIt concept]
- Regulator of G-Protein Signaling 4 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- Sclerostin [NCIt concept]
- Sclerostin Domain-Containing Protein 1 [NCIt concept]
- Sprouty-Related, EVH1 Domain-Containing Protein 1 [NCIt concept]
- Sprouty-Related, EVH1 Domain-Containing Protein 2 [NCIt concept]
- TNFAIP3-Interacting Protein 1 [NCIt concept]
- Transmembrane Protein 127 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 [NCIt concept]
- Ubiquitin-Associated and SH3 Domain-Containing Protein A [NCIt concept]
- Uracil Nucleotide/Cysteinyl Leukotriene Receptor [NCIt concept]
- Wnt Inhibitory Factor 1 [NCIt concept]
- Xanthine Dehydrogenase/Oxidase [NCIt concept]
biological_process_is_part_of_process
- Intercellular Communication Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Afatinib [NCIt concept]
- Afatinib Dimaleate [NCIt concept]
- Allitinib [NCIt concept]
- Alvespimycin [NCIt concept]
- Alvespimycin Hydrochloride [NCIt concept]
- Angiogenesis Inhibitor JI-101 [NCIt concept]
- Aurora Kinase Inhibitor AMG 900 [NCIt concept]
- Aurora Kinase Inhibitor SNS-314 [NCIt concept]
- Axl/Mer Inhibitor INCB081776 [NCIt concept]
- Axl/Mer Inhibitor PF-07265807 [NCIt concept]
- Axl/Mer/CSF1R Inhibitor Q702 [NCIt concept]
- BCR-ABL Inhibitor [NCIt concept]
- BCR-ABL Inhibitor ELVN-001 [NCIt concept]
- BCR-ABL Inhibitor HS-10382 [NCIt concept]
- BCR-ABL Inhibitor TGRX-678 [NCIt concept]
- BMX Inhibitor [NCIt concept]
- Bafetinib [NCIt concept]
- Bevacizumab [NCIt concept]
- Bortezomib [NCIt concept]
- Bosutinib [NCIt concept]
- Bosutinib Monohydrate [NCIt concept]
- Brivanib [NCIt concept]
- Bryostatin 1 [NCIt concept]
- Carboxyamidotriazole [NCIt concept]
- Cediranib Maleate [NCIt concept]
- Crenolanib [NCIt concept]
- Crenolanib Besylate [NCIt concept]
- Dasatinib [NCIt concept]
- Dasatinib Anhydrous [NCIt concept]
- Dasatinib Laurylsulfate [NCIt concept]
- Decernotinib [NCIt concept]
- Edicotinib [NCIt concept]
- Erlotinib Hydrochloride [NCIt concept]
- Flutamide [NCIt concept]
- Gefitinib [NCIt concept]
- Geldanamycin Analogue [NCIt concept]
- Halofuginone [NCIt concept]
- Henatinib Maleate [NCIt concept]
- Herbimycin [NCIt concept]
- Hsp90 Inhibitor BIIB021 [NCIt concept]
- Ibrutinib [NCIt concept]
- Imatinib [NCIt concept]
- Imatinib Mesylate [NCIt concept]
- Ixazomib [NCIt concept]
- Ixazomib Citrate [NCIt concept]
- Lifirafenib [NCIt concept]
- Marizomib [NCIt concept]
- Masitinib [NCIt concept]
- Masitinib Mesylate [NCIt concept]
- Metatinib Tromethamine [NCIt concept]
- Multikinase Inhibitor AT9283 [NCIt concept]
- Nilotinib [NCIt concept]
- Nilotinib Hydrochloride Anhydrous [NCIt concept]
- Nilotinib Hydrochloride Monohydrate [NCIt concept]
- Nintedanib [NCIt concept]
- Olverembatinib [NCIt concept]
- Pegdinetanib [NCIt concept]
- Polo-like Kinase 1 Inhibitor GSK461364 [NCIt concept]
- Polo-like Kinase 1 Inhibitor MK1496 [NCIt concept]
- Ponatinib [NCIt concept]
- Ponatinib Hydrochloride [NCIt concept]
- Ranibizumab [NCIt concept]
- Retaspimycin [NCIt concept]
- Retaspimycin Hydrochloride [NCIt concept]
- Ridaforolimus [NCIt concept]
- Rigosertib Sodium [NCIt concept]
- Salt-inducible Kinase Inhibitor GRN-300 [NCIt concept]
- Saracatinib [NCIt concept]
- Saracatinib Difumarate [NCIt concept]
- Sorafenib Tosylate [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- Tanespimycin [NCIt concept]
- Temsirolimus [NCIt concept]
- Tesevatinib [NCIt concept]
- Tinengotinib [NCIt concept]
- Tipifarnib [NCIt concept]
- Tivozanib [NCIt concept]
- VEGFR/PDGFR Tyrosine Kinase Inhibitor TAK-593 [NCIt concept]
- Vamotinib [NCIt concept]
- Varlitinib [NCIt concept]
- Varlitinib Tosylate [NCIt concept]
- Vodobatinib [NCIt concept]
- cFMS Tyrosine Kinase Inhibitor ARRY-382 [NCIt concept]
process_involves_gene
- ACHE Gene [NCIt concept]
- ACHE wt Allele [NCIt concept]
- BAMBI Gene [NCIt concept]
- BAMBI wt Allele [NCIt concept]
- BICC1 Gene [NCIt concept]
- BICC1 wt Allele [NCIt concept]
- CABIN1 Gene [NCIt concept]
- CABIN1 wt Allele [NCIt concept]
- CALR Gene [NCIt concept]
- CALR wt Allele [NCIt concept]
- CBLC Gene [NCIt concept]
- CBLC wt Allele [NCIt concept]
- DEPTOR Gene [NCIt concept]
- DEPTOR wt Allele [NCIt concept]
- DKK1 Gene [NCIt concept]
- DKK1 wt Allele [NCIt concept]
- DKK2 Gene [NCIt concept]
- DKK2 wt Allele [NCIt concept]
- DKK3 Gene [NCIt concept]
- DKK3 wt Allele [NCIt concept]
- DKK4 Gene [NCIt concept]
- DKK4 wt Allele [NCIt concept]
- ERRFI1 Gene [NCIt concept]
- ERRFI1 wt Allele [NCIt concept]
- FSTL3 Gene [NCIt concept]
- FSTL3 wt Allele [NCIt concept]
- HEY1 Gene [NCIt concept]
- HEY1 wt Allele [NCIt concept]
- LEMD3 Gene [NCIt concept]
- LEMD3 wt Allele [NCIt concept]
- LEPROTL1 Gene [NCIt concept]
- LEPROTL1 wt Allele [NCIt concept]
- LRP4 Gene [NCIt concept]
- LRP4 wt Allele [NCIt concept]
- NR1D1 Gene [NCIt concept]
- NR1D1 wt Allele [NCIt concept]
- PFN1 Gene [NCIt concept]
- PFN1 wt Allele [NCIt concept]
- RASA2 Gene [NCIt concept]
- RASA2 wt Allele [NCIt concept]
- RASAL1 Gene [NCIt concept]
- RASAL1 wt Allele [NCIt concept]
- RASAL2 Gene [NCIt concept]
- RASAL2 wt Allele [NCIt concept]
- RASSF7 Gene [NCIt concept]
- RASSF7 wt Allele [NCIt concept]
- RGS22 Gene [NCIt concept]
- RGS22 wt Allele [NCIt concept]
- RGS4 Gene [NCIt concept]
- RGS4 wt Allele [NCIt concept]
- RNF43 Gene [NCIt concept]
- RNF43 wt Allele [NCIt concept]
- RPS6KA6 Gene [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]
- SOST Gene [NCIt concept]
- SOST wt Allele [NCIt concept]
- SOSTDC1 Gene [NCIt concept]
- SOSTDC1 wt Allele [NCIt concept]
- SPRED1 Gene [NCIt concept]
- SPRED1 wt Allele [NCIt concept]
- SPRED2 Gene [NCIt concept]
- SPRED2 wt Allele [NCIt concept]
- SPRY2 Gene [NCIt concept]
- SPRY2 wt Allele [NCIt concept]
- SPRY4 Gene [NCIt concept]
- SPRY4 wt Allele [NCIt concept]
- TMEM127 Gene [NCIt concept]
- TMEM127 wt Allele [NCIt concept]
- TNIP1 Gene [NCIt concept]
- TNIP1 wt Allele [NCIt concept]
- UBASH3A Gene [NCIt concept]
- UBASH3A wt Allele [NCIt concept]
- UCHL1 Gene [NCIt concept]
- UCHL1 wt Allele [NCIt concept]
- WIF1 Gene [NCIt concept]
- WIF1 wt Allele [NCIt concept]
- WWC1 Gene [NCIt concept]
- WWC1 wt Allele [NCIt concept]
- XDH Gene [NCIt concept]
- XDH wt Allele [NCIt concept]
- ZNRF3 Gene [NCIt concept]
- ZNRF3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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