" /> Varlitinib - CISMeF





Preferred Label : Varlitinib;

NCIt definition : An orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.;

UNII : 846Y8197W1;

InChIKey : UWXSAYUXVSFDBQ-CYBMUJFWSA-N;

CAS number : 845272-21-1;

Molecule name : ARRY-334543;

Chemical formula : C22H19ClN6O2S;

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09/05/2025


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