NCIt definition : An orally bioavailable inhibitor of the epidermal growth factor receptor family with
potential antineoplastic activity. Varlitinib selectively and reversibly binds to
both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation,
which may result in inhibition of the associated signal transduction pathways, inhibition
of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell
proliferation and differentiation and are upregulated in various human tumor cell
types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically
more effective than agents that inhibit EGFR or Her-2 alone.;
UNII : 846Y8197W1;
InChIKey : UWXSAYUXVSFDBQ-CYBMUJFWSA-N;
CAS number : 845272-21-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 845272-21-1
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