Preferred Label : Varlitinib Tosylate;
NCIt synonyms : 4,6-Quinazolinediamine, N(Sup 4)-(3-Chloro-4-(2-Thiazolylmethoxy)Phenyl)-N(Sup 6)-((4r)-4,5-Dihydro-4-Methyl-2-Oxazolyl)-,
4-Methylbenzenesulphonate (1:2); 4-N-(3-Chloro-4-(Thiazol-2-Ylmethoxy)Phenyl)-6-N-((4r)-4-Methyl-4,5-Dihydrooxazol-2-
Yl)Quinazoline-4,6-Diamine Bis(4-Methylbenzenesulphonate);
NCIt definition : The tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal
growth factor receptor family with potential antineoplastic activity. Varlitinib selectively
and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their
phosphorylation and activation, which may result in inhibition of the associated signal
transduction pathways, inhibition of cellular proliferation and cell death. EGFR and
Her-2 play important roles in cell proliferation and differentiation and are upregulated
in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2,
this agent may be therapeutically more effective than agents that inhibit EGFR or
Her-2 alone.;
UNII : V4M8FWS152;
InChIKey : QSUPQMGDXOHVLK-FFXKMJQXSA-N;
CAS number : 1146629-86-8;
Molecule name : AR00334543 Ditosylate; ARRY-334543 Ditosylate; ARRY-543 Ditosylate; AR00334543 Ditosilate; ARRY-543 Ditosilate;
Chemical formula : C22H19ClN6O2S.2C7H8O3S;
Origin ID : C95226;
UMLS CUI : C2987008;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
