" /> Erlotinib Hydrochloride - CISMeF





Preferred Label : Erlotinib Hydrochloride;

NCIt synonyms : N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride; Erlotinib;

NCIt related terms : Tarceva; OSI-774; CP-358,774;

NCIt definition : The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.;

Alternative definition : NCI-GLOSS: A drug used to treat certain types of non-small cell lung cancer. It is also used together with gemcitabine to treat pancreatic cancer and is being studied in the treatment of other types of cancer. Erlotinib hydrochloride is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.;

UNII : DA87705X9K;

InChIKey : GTTBEUCJPZQMDZ-UHFFFAOYSA-N;

CAS number : 183319-69-9;

Drug name : Tarceva;

Molecule name : OSI-774; Cp-358,774; CP-358; OSI 774; CP 358;

Chemical formula : C22H23N3O4.HCl;

NSC code : 718781;

ChEBI ID : CHEBI:53509;

Codes from synonyms : CDR0000508934; 50311; CDR0000508938; CDR0000508929; CDR0000045101;

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04/05/2025


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