Erlotinib - CISMeF

Preferred Label : Erlotinib;

NCIt synonyms : Erlotinib Base;

NCIt definition : A quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.;

UNII : J4T82NDH7E;

InChIKey : AAKJLRGGTJKAMG-UHFFFAOYSA-N;

CAS number : 183321-74-6;

Chemical formula : C22H23N3O4;

ChEBI ID : CHEBI:114785;

Codes from synonyms : CDR0000045046; 198;

Details

Origin ID

C65530;

UMLS CUI

C1135135;

Automatic exact mappings (from CISMeF team)
- erlotinib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- Erlotinib Hydrochloride [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Erlotinib Hydrochloride [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_free_acid_or_base_form_of
- Erlotinib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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