Low-Density Lipoprotein Receptor-Related Protein 4

Preferred Label : Low-Density Lipoprotein Receptor-Related Protein 4;

NCIt synonyms : Multiple Epidermal Growth Factor-Like Domains 7; Low Density Lipoprotein Receptor-Related Protein 4; LRP-4;

NCIt related terms : Sclerosteosis 2; LRP4; MEGF7; LDL Receptor Related Protein 4; SOST2;

NCIt definition : Low-density lipoprotein receptor-related protein 4 (1905 aa, 212 kDa) is encoded by the human LRP4 gene. This protein plays a role in agrin and sclerostin binding and the propagation of ligand-dependent signal transduction.;

Alternative definition : CDISC: An antigen encoded by the LRP4 gene and a regulator of the Wnt signaling that is involved in neuromuscular junction formation. It can be considered as an autoantigen and is commonly associated with the autoimmune disease myasthenia gravis.;

Details

Origin ID

C203629;

UMLS CUI

C2973421;

OMIM relation
- Low density lipoprotein receptor-related protein 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LRP4 protein, human [MeSH Supplementary Concept]
- LRP4 protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- LRP4 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]

Keyword's position in hierarchy(ies) :

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