Preferred Label : EGF-Like Domain;
NCIt definition : A sequence of about thirty to forty amino-acid residues long found in the sequence
of epidermal growth factor (EGF) has been shown to be present, in a conserved form,
in a large number of other, mostly animal proteins. The list of proteins currently
known to contain one or more copies of an EGF-like pattern is large and varied. The
functional significance of EGF domains in what appear to be unrelated proteins is
not yet clear. However, a common feature is that these repeats are found in the extracellular
domain of membrane-bound proteins or in proteins known to be secreted (exception:
prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have
been shown (in EGF) to be involved in disulfide bonds. The main structure is a two-stranded
beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains
between the conserved cysteines vary in length. (InterPro IPR006209);
Origin ID : C13937;
UMLS CUI : C1512115;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
