Delta and Notch-Like Epidermal Growth Factor-Related Receptor

Preferred Label : Delta and Notch-Like Epidermal Growth Factor-Related Receptor;

NCIt synonyms : Delta-Notch-Like EGF Repeat-Containing Transmembrane; Delta- and Notch-Like EGF-Related Receptor;

NCIt related terms : PCA-Tr Antigen; DENR; Tr Antigen; Purkinje Cell Cytoplasmic-Tr; PURKINJE CELL CYTOPLASMIC TYPE TR ANTIGEN;

NCIt definition : Delta and Notch-like epidermal growth factor-related receptor (737 aa, 78 kDa) is encoded by the human DNER gene. This protein plays a role in the positive regulation of Notch signaling.;

Alternative definition : CDISC: An antigen encoded by the DENR gene and regulates Notch-mediated signaling and central nervous system development. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative disorders related to cancer, such as paraneoplastic cerebellar degeneration.;

Details

Origin ID

C115972;

UMLS CUI

C1257727;

Automatic exact mappings (from CISMeF team)
- Delta- and notch-like epidermal growth factor-related receptor [OMIM gene]
OMIM relation
- Delta- and notch-like epidermal growth factor-related receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- DNER protein, human [MeSH Supplementary Concept]
- DNER protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- DNER Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Dendrite [NCIt concept]
- Early Endosome [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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