Coagulation Factor IX

Preferred Label : Coagulation Factor IX;

NCIt synonyms : Factor IX; Christmas Factor; EC 3.4.21.22; F9; Coagulation Factor-IX; Factor 9; PTC; Plasma Thromboplastin Component; Plasma Thromboplastic Component;

NCIt definition : Coagulation factor IX (461 aa, 52 kDa) is encoded by the human F9 gene. This protein plays a role in the intrinsic pathway of blood coagulation through the mediation of proteolysis that converts factor X into an active protease.;

NCIt note : Coagulation factor IX is converted from a zymogen to an active protease through a single proteolytic cleavage by either coagulation factor XIa or a complex containing tissue factor and coagulation factor IIVa.;

Details

Origin ID

C28482;

UMLS CUI

C0724584;

Currated CISMeF NLP mapping
- Christmas factor [MedDRA LLT]
- Coagulation factor IX (substance) [SNOMED CT concept]
- Factor IX [PASCAL descriptor]
- Factor IX [LOINC component]
- blood-coagulation factor ix [Substance BNPC]
- coagulation factor ix [SNOMED Notion]
- factor IX [Blood Transfusion thesaurus concept]
- factor IX [MeSH Descriptor]
- factor IX [MeSH concept]
False automatic mappings
- factor IX (1-47) [MeSH concept]
- factor IX (1-47) [MeSH Supplementary Concept]
OMIM relation
- Coagulation factor ix [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- F9 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Hemophilia B [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Coagulation Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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