Complement and Coagulation Cascade

Preferred Label : Complement and Coagulation Cascade;

NCIt related terms : Complement and coagulation cascades;

Alternative definition : KEGG: The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsinization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.;

KEGG ID : hsa04610;

Details

Origin ID

C91511;

UMLS CUI

C2984320;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Alpha-2-Antiplasmin [NCIt concept]
- Antithrombin-III [NCIt concept]
- B1 Bradykinin Receptor [NCIt concept]
- B2 Bradykinin Receptor [NCIt concept]
- C3a Anaphylatoxin Chemotactic Receptor [NCIt concept]
- C5a Anaphylatoxin Chemotactic Receptor 1 [NCIt concept]
- CD59 Glycoprotein [NCIt concept]
- Carboxypeptidase B2 [NCIt concept]
- Coagulation Factor IX [NCIt concept]
- Coagulation Factor V [NCIt concept]
- Coagulation Factor VII [NCIt concept]
- Coagulation Factor VIII [NCIt concept]
- Coagulation Factor X [NCIt concept]
- Coagulation Factor XI [NCIt concept]
- Coagulation Factor XII [NCIt concept]
- Complement C1q Subcomponent Subunit A [NCIt concept]
- Complement C1q Subcomponent Subunit B [NCIt concept]
- Complement C1q Subcomponent Subunit C [NCIt concept]
- Complement C1r Subcomponent [NCIt concept]
- Complement C1s Subcomponent [NCIt concept]
- Complement C2 [NCIt concept]
- Complement C4-A [NCIt concept]
- Complement C4-B [NCIt concept]
- Complement Component C6 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]
- Complement Decay-Accelerating Factor [NCIt concept]
- Complement Factor B [NCIt concept]
- Complement Factor H [NCIt concept]
- Complement Factor H-Related Protein 1 [NCIt concept]
- Complement Factor H-Related Protein 5 [NCIt concept]
- Complement Factor I [NCIt concept]
- Complement Receptor Type 2 [NCIt concept]
- Fibrinogen Alpha Chain [NCIt concept]
- Heparin Cofactor 2 [NCIt concept]
- Kininogen-1 [NCIt concept]
- Mannan-Binding Lectin Serine Protease 2 [NCIt concept]
- Membrane Cofactor Protein [NCIt concept]
- Plasma Kallikrein [NCIt concept]
- Plasma Protease C1 Inhibitor [NCIt concept]
- Plasminogen [NCIt concept]
- Protease-Activated Receptor 1 [NCIt concept]
- Prothrombin [NCIt concept]
- Thrombomodulin [NCIt concept]
- Tissue Factor [NCIt concept]
- Tissue Factor Pathway Inhibitor [NCIt concept]
- Urokinase Plasminogen Activator Surface Receptor [NCIt concept]
- Urokinase-Type Plasminogen Activator [NCIt concept]
- V-Set and Immunoglobulin Domain-Containing Protein 4 [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Vitamin K-Dependent Protein S [NCIt concept]
- Vitronectin [NCIt concept]
- von Willebrand Factor [NCIt concept]
pathway_has_gene_element
- BDKRB1 wt Allele [NCIt concept]
- BDKRB2 wt Allele [NCIt concept]
- C1QA wt Allele [NCIt concept]
- C1QB wt Allele [NCIt concept]
- C1QC wt Allele [NCIt concept]
- C1R wt Allele [NCIt concept]
- C1S wt Allele [NCIt concept]
- C2 wt Allele [NCIt concept]
- C3AR1 wt Allele [NCIt concept]
- C4A wt Allele [NCIt concept]
- C4B wt Allele [NCIt concept]
- C5AR1 wt Allele [NCIt concept]
- C6 wt Allele [NCIt concept]
- C8A wt Allele [NCIt concept]
- C8B wt Allele [NCIt concept]
- C8G wt Allele [NCIt concept]
- C9 wt Allele [NCIt concept]
- CD46 wt Allele [NCIt concept]
- CD55 wt Allele [NCIt concept]
- CD59 wt Allele [NCIt concept]
- CFB wt Allele [NCIt concept]
- CFH wt Allele [NCIt concept]
- CFHR1 wt Allele [NCIt concept]
- CFHR5 wt Allele [NCIt concept]
- CFI wt Allele [NCIt concept]
- CPB2 wt Allele [NCIt concept]
- CR2 wt Allele [NCIt concept]
- F10 wt Allele [NCIt concept]
- F11 wt Allele [NCIt concept]
- F12 wt Allele [NCIt concept]
- F2 wt Allele [NCIt concept]
- F2R wt Allele [NCIt concept]
- F3 wt Allele [NCIt concept]
- F5 wt Allele [NCIt concept]
- F7 wt Allele [NCIt concept]
- F8 wt Allele [NCIt concept]
- F9 wt Allele [NCIt concept]
- FGA wt Allele [NCIt concept]
- KLKB1 wt Allele [NCIt concept]
- KNG1 wt Allele [NCIt concept]
- MASP2 wt Allele [NCIt concept]
- PLAT wt Allele [NCIt concept]
- PLAU wt Allele [NCIt concept]
- PLAUR wt Allele [NCIt concept]
- PLG wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- PROS1 wt Allele [NCIt concept]
- SERPINC1 wt Allele [NCIt concept]
- SERPIND1 wt Allele [NCIt concept]
- SERPINF2 wt Allele [NCIt concept]
- SERPING1 wt Allele [NCIt concept]
- TFPI wt Allele [NCIt concept]
- THBD wt Allele [NCIt concept]
- VSIG4 wt Allele [NCIt concept]
- VTN wt Allele [NCIt concept]
- VWF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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