Vitamin K-Dependent Protein C

Preferred Label : Vitamin K-Dependent Protein C;

NCIt synonyms : EC 3.4.21.69; Protein C; Autoprothrombin IIA; Anticoagulant Protein C; Blood Coagulation Factor XIV; PROC;

NCIt definition : Vitamin K-dependent protein C (461 aa, 52 kDa) is encoded by the human PROC gene. This protein is involved in the degradation of factors Va and VIIIa.;

NCIt note : Thrombin cleavage of the vitamin K-dependent protein C precursor is required for its enzymatic activity. (UniProt);

NCI Metathesaurus CUI : CL524129;

Details

Origin ID

C102826;

UMLS CUI

C1949480;

Currated CISMeF NLP mapping
- Protein C [LOINC component]
- Protein C [MedDRA Preferred Term]
- Protein C [ICD-11 Extension code]
- Protein C [SMS substance]
- Protein C (substance) [SNOMED CT concept]
- protein C [MeSH Descriptor]
- protein C [MeSH concept]
- protein C [Blood Transfusion thesaurus concept]
- protein c, nos [SNOMED Notion]
OMIM relation
- Protein C [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PROC Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Plasma [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myocardial Infarction Pathway [NCIt concept]
- Beta-Catenin Accumulation Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Extrinsic Prothrombin Activation Pathway [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
- Pitx2 Transcription Regulation Pathway [NCIt concept]
- Segmentation Clock Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Coagulation [NCIt concept]
- Protein Turnover [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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