Segmentation Clock Pathway

Preferred Label : Segmentation Clock Pathway;

NCIt related terms : Segmentation Clock;

Alternative definition : BIOCARTA: In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_hesPathway;

Details

Origin ID

C39104;

UMLS CUI

C1519227;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dickkopf-Related Protein 1 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 17 [NCIt concept]
- Frizzled-1 [NCIt concept]
- Gamma Secretase [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Hairy/Enhancer-Of-Split Related With YRPW Motif Protein 2 [NCIt concept]
- Hepatocyte Nuclear Factor 1-Alpha [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 6 [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 1 [NCIt concept]
- Neurogenic Locus Notch Homolog Protein 2 [NCIt concept]
- Presenilin-1 [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- Recombining Binding Protein Suppressor of Hairless [NCIt concept]
- Transcription Factor HES-1 [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Wnt Inhibitory Factor 1 [NCIt concept]
pathway_has_gene_element
- ADAM17 wt Allele [NCIt concept]
- DKK1 wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HES1 wt Allele [NCIt concept]
- HEY2 wt Allele [NCIt concept]
- HNF1A wt Allele [NCIt concept]
- LRP6 wt Allele [NCIt concept]
- NOTCH1 wt Allele [NCIt concept]
- NOTCH2 wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- PSEN1 wt Allele [NCIt concept]
- RBPJ wt Allele [NCIt concept]
- WIF1 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]

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