Preferred Label : Segmentation Clock Pathway;
NCIt related terms : Segmentation Clock;
Alternative definition : BIOCARTA: In most animal species, the anteroposterior body axis is generated by the
formation of repeated structures called segments. In vertebrate segmentation, a specialized
mesodermal structure called the somite gives rise to skeletal muscles, vertebrae,
and some dermis. Formation of the somites is a rhythmic process that involves an oscillator,
the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite
precursors and halts when they reach a specific maturation stage defined as the wavefront,
established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of
Notch and to bind and negatively regulate its own promoter. Another cyclic gene is
hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively
regulate its own promoter too. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_hesPathway;
Origin ID : C39104;
UMLS CUI : C1519227;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element