Intrinsic Prothrombin Activation Pathway

Preferred Label : Intrinsic Prothrombin Activation Pathway;

Alternative definition : BIOCARTA: Blood coagulation or clotting takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. The prothrombin activation complex is formed by two pathways each of which results in a different form of the prothrombin activator. The intrinsic mechanism of prothrombin activator formation begins with trauma to the blood or exposure of blood to collagen in a traumatized vessel wall. This usually also results in damage to fragile platelets. The formation of a clot by this mechanism usually takes 1 to 6 minutes. This cascade begins with the activation of factor XII and the release of platelet factor 3 (PF3) from damaged platelets. Activated factor XII cleaves and actives factor XI and prekallikrein (PK). Factor XII is also activated by activated prekallikrein (aPK) in an internal amplification loop. Calcium (Ca ) is required for the initial three steps. The prothrombin activator in the intrinsic pathway is very similar to the activator in the extrinsic pathway. Antithrombin III inhibits the activity of thrombin and also two of the steps in the formation of the activator. Protein C is activated by thrombin and with the Protein S cofactor provides a strong negative feedback in this phase of clot formation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_intrinsicPathway;

Details

Origin ID

C39132;

UMLS CUI

C1517573;

Semantic type(s)
- Organ or Tissue Function [UMLS semantic type]
has_gene_product_element
- Coagulation Factor IX [NCIt concept]
- Coagulation Factor V [NCIt concept]
- Coagulation Factor VIII [NCIt concept]
- Coagulation Factor X [NCIt concept]
- Coagulation Factor XI [NCIt concept]
- Coagulation Factor XII [NCIt concept]
- Collagen Alpha-2(IV) Chain [NCIt concept]
- Collagen Alpha-3(IV) Chain [NCIt concept]
- Collagen Alpha-6(IV) Chain [NCIt concept]
- Fibrinogen Alpha Chain [NCIt concept]
- Kininogen-1 [NCIt concept]
- Plasma Kallikrein [NCIt concept]
- Protease-Activated Receptor 1 [NCIt concept]
- Prothrombin [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Vitamin K-Dependent Protein S [NCIt concept]
pathway_has_gene_element
- COL4A2 wt Allele [NCIt concept]
- COL4A3 wt Allele [NCIt concept]
- COL4A6 wt Allele [NCIt concept]
- F10 wt Allele [NCIt concept]
- F11 wt Allele [NCIt concept]
- F12 wt Allele [NCIt concept]
- F2 wt Allele [NCIt concept]
- F2R wt Allele [NCIt concept]
- F5 wt Allele [NCIt concept]
- F8 wt Allele [NCIt concept]
- F9 wt Allele [NCIt concept]
- FGA wt Allele [NCIt concept]
- KLKB1 wt Allele [NCIt concept]
- KNG1 wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- PROS1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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