Protease-Activated Receptor 1

Preferred Label : Protease-Activated Receptor 1;

NCIt synonyms : Thrombin Receptor; Coagulation Factor-II Receptor; F2R; Coagulation Factor II Receptor; PAR-1;

NCIt definition : Proteinase-activated receptor 1 (425 aa, 47 kDa) is encoded by the human F2R gene. This protein plays a role in thrombin-dependent G protein-coupled receptor signaling.;

NCIt note : Expressed in platelets and vascular endothelia by human F2R Gene (GPCR1 Family), 425-aa 47-kDa (precursor) Coagulation Factor II Receptor is a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desensitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand.;

Details

Origin ID

C26105;

UMLS CUI

C4048327;

Currated CISMeF NLP mapping
- receptors, thrombin [MeSH Descriptor]
- receptors, thrombin [MeSH concept]
OMIM relation
- Coagulation factor II receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- F2R Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Endothelial Cell [NCIt concept]
- Platelet [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myocardial Infarction Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Extrinsic Prothrombin Activation Pathway [NCIt concept]
- Fibrinolysis Pathway [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Thrombin/Protease-Activated Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Motility [NCIt concept]
- Coagulation Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Morphogenesis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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