receptors, thrombin

Preferred Label : receptors, thrombin;

MeSH definition : A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.;

MeSH synonym : thrombin receptors; thrombin receptor; receptor, thrombin;

MeSH hyponym : thrombin receptor activating peptides; Thrombin Receptor Activating Peptide Ligand; TRAP Peptide; Peptide, TRAP; Thrombin Receptor Activator Peptide;

MeSH annotation : DF: RECEPT THROMBIN;

Wikipedia link : https://en.wikipedia.org/wiki/Thrombin receptors;

Is substance : O;

Details

Origin ID

D018179;

UMLS CUI

C0076552;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Currated CISMeF NLP mapping
- Protease-Activated Receptor 1 [NCIt concept]
Indexing information
- 1-(6-guanidohexanoyl)-4-(phenylacetylaminomethyl)piperidine [MeSH Supplementary Concept]
- 1-phenylacetyl-4-(6-guanidohexanoyl)piperazine [MeSH Supplementary Concept]
- 4-(5-(3-trifluoromethylphenyl)pyridin-2-yl)ethenyl-3-methyldecahydronaphtho(2,3-c)furan-1(3H)-one [MeSH Supplementary Concept]
- 5-(3-(hexahydroazepin-1-yl)propyl)(benzodioxol-5-yl)amino-3-(3,5-difluorophenyl)isoxazole [MeSH Supplementary Concept]
- E 5555 [MeSH Supplementary Concept]
- FR 171113 [MeSH Supplementary Concept]
- N-cinnamoyl-4-fluorophenylalanyl-4-guanidinophenylalanyl-leucyl-arginyl-argininamide [MeSH Supplementary Concept]
- N-cinnamoyl-p-fluorophenylalanyl-p-guanidinophenylalanyl-leucyl-argininamide [MeSH Supplementary Concept]
- RWJ 58259 [MeSH Supplementary Concept]
- RWJ-53052 [MeSH Supplementary Concept]
- RWJ-56110 [MeSH Supplementary Concept]
- SFLLRNPND [MeSH Supplementary Concept]
- aplysillin A [MeSH Supplementary Concept]
- decahydro-7-hydroxy-3-methyl-4-(2-(5-(3-(trifluoromethyl)phenyl)-2-pyridinyl)ethenyl)naphtho(2,3-c)furan-1(3H)-one [MeSH Supplementary Concept]
- eryloside F [MeSH Supplementary Concept]
- seryl-leucyl-isoleucyl-glycyl-arginyl-leucine [MeSH Supplementary Concept]
- seryl-phenylalanyl-phenylalanyl-leucyl-arginyl-asparaginyl-proline [MeSH Supplementary Concept]
- thrombin receptor peptide (1-41) [MeSH Supplementary Concept]
- thrombin receptor peptide (42-47) [MeSH Supplementary Concept]
- thrombin receptor peptide (42-55) [MeSH Supplementary Concept]
- thrombin receptor peptide 14 [MeSH Supplementary Concept]
- thrombin receptor-activating peptide SFLLRNPNDKY [MeSH Supplementary Concept]
- vorapaxar [MeSH Supplementary Concept]
Record concept(s)
- receptors, thrombin [MeSH concept]
- thrombin receptor activating peptides [MeSH concept]
Related MeSH Supplementary Concept(s)
- protease-activated receptor 3 [MeSH Supplementary Concept]
- protease-activated receptor 4 [MeSH Supplementary Concept]
- solulin protein [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- thrombin [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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