Calcium-Mediated Signaling Pathway

Preferred Label : Calcium-Mediated Signaling Pathway;

NCIt related terms : Calcium signaling pathway;

Alternative definition : KEGG: Ca2 that enters the cell from the outside is a principal source of signal Ca2 . Entry of Ca2 is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2 by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2 fluxes that control fast cellular processes. There are many other Ca2 -entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).;

KEGG ID : hsa04020;

Details

Origin ID

C91460;

UMLS CUI

C2984272;

Automatic exact mappings (from CISMeF team)
- calcium signaling [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Epsilon-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- 5-Hydroxytryptamine Receptor 2A [NCIt concept]
- 5-Hydroxytryptamine Receptor 2C [NCIt concept]
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]
- ADP/ATP Translocase 1 [NCIt concept]
- ADP/ATP Translocase 2 [NCIt concept]
- ADP/ATP Translocase 3 [NCIt concept]
- Adenosine Receptor A2a [NCIt concept]
- Adenosine Receptor A2b [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Alpha-1A Adrenergic Receptor [NCIt concept]
- Alpha-1B Adrenergic Receptor [NCIt concept]
- B1 Bradykinin Receptor [NCIt concept]
- B2 Bradykinin Receptor [NCIt concept]
- Beta-1 Adrenergic Receptor [NCIt concept]
- Beta-2 Adrenergic Receptor [NCIt concept]
- Beta-3 Adrenergic Receptor [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Calcium Release-Activated Calcium Channel Protein 1 [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Calsequestrin-2 [NCIt concept]
- Cardiac Phospholamban [NCIt concept]
- Cholecystokinin Receptor Type A [NCIt concept]
- Cysteinyl Leukotriene Receptor 2 [NCIt concept]
- D(1A) Dopamine Receptor [NCIt concept]
- D(1B) Dopamine Receptor [NCIt concept]
- Endothelin Receptor Type B [NCIt concept]
- Endothelin-1 Receptor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Gastrin-Releasing Peptide Receptor [NCIt concept]
- Gastrin/Cholecystokinin Type B Receptor [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2A [NCIt concept]
- Glutamate Receptor Ionotropic, NMDA 2D [NCIt concept]
- Histamine H2 Receptor [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Inositol-Trisphosphate 3-Kinase B [NCIt concept]
- Inositol-Trisphosphate 3-Kinase C [NCIt concept]
- Junctin-1 [NCIt concept]
- Junctin-2 [NCIt concept]
- Lutropin-Choriogonadotropic Hormone Receptor [NCIt concept]
- Metabotropic Glutamate Receptor 1 [NCIt concept]
- Metabotropic Glutamate Receptor 5 [NCIt concept]
- Mucolipin-1 [NCIt concept]
- Muscarinic Acetylcholine Receptor M1 [NCIt concept]
- Muscarinic Acetylcholine Receptor M3 [NCIt concept]
- Muscarinic Acetylcholine Receptor M5 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- Neuromedin-K Receptor [NCIt concept]
- Neurotensin Receptor Type 1 [NCIt concept]
- Nitric Oxide Synthase, Brain [NCIt concept]
- Nitric Oxide Synthase, Endothelial [NCIt concept]
- Nitric Oxide Synthase, Inducible [NCIt concept]
- P2X Purinoceptor 2 [NCIt concept]
- Peptidyl-Prolyl Cis-Trans Isomerase F, Mitochondrial [NCIt concept]
- Plasma Membrane Calcium-Transporting ATPase 3 [NCIt concept]
- Protease-Activated Receptor 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Ryanodine Receptor 1 [NCIt concept]
- Ryanodine Receptor 2 [NCIt concept]
- Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Sodium/Calcium Exchanger 1 [NCIt concept]
- Sphingosine Kinase 1 [NCIt concept]
- Sphingosine Kinase 2 [NCIt concept]
- Stromal Interaction Molecule 1 [NCIt concept]
- Substance-P Receptor [NCIt concept]
- Thromboxane A2 Receptor [NCIt concept]
- Two Pore Channel Protein 2 [NCIt concept]
- Type-1 Angiotensin II Receptor [NCIt concept]
- Vasopressin V1A Receptor [NCIt concept]
- Vasopressin V1B Receptor [NCIt concept]
- Voltage-Dependent Anion-Selective Channel Protein 1 [NCIt concept]
- Voltage-Dependent Anion-Selective Channel Protein 2 [NCIt concept]
- Voltage-Dependent Anion-Selective Channel Protein 3 [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S [NCIt concept]
- Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A [NCIt concept]
- Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1E [NCIt concept]
- Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- ADORA2A wt Allele [NCIt concept]
- ADORA2B wt Allele [NCIt concept]
- ADRA1A wt Allele [NCIt concept]
- ADRA1B wt Allele [NCIt concept]
- ADRB1 wt Allele [NCIt concept]
- ADRB2 wt Allele [NCIt concept]
- ADRB3 wt Allele [NCIt concept]
- AGTR1 wt Allele [NCIt concept]
- ASPH wt Allele [NCIt concept]
- ATP2A2 wt Allele [NCIt concept]
- ATP2B3 wt Allele [NCIt concept]
- AVPR1A wt Allele [NCIt concept]
- AVPR1B wt Allele [NCIt concept]
- BDKRB1 wt Allele [NCIt concept]
- BDKRB2 wt Allele [NCIt concept]
- CACNA1A wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1G wt Allele [NCIt concept]
- CACNA1S wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CASQ2 wt Allele [NCIt concept]
- CCKAR wt Allele [NCIt concept]
- CCKBR wt Allele [NCIt concept]
- CD38 wt Allele [NCIt concept]
- CHRM1 wt Allele [NCIt concept]
- CHRM3 wt Allele [NCIt concept]
- CHRM5 wt Allele [NCIt concept]
- CYSLTR2 wt Allele [NCIt concept]
- DRD1 wt Allele [NCIt concept]
- DRD5 wt Allele [NCIt concept]
- EDNRA wt Allele [NCIt concept]
- EDNRB wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- F2R wt Allele [NCIt concept]
- GRIN2A wt Allele [NCIt concept]
- GRIN2D wt Allele [NCIt concept]
- GRM1 wt Allele [NCIt concept]
- GRM5 wt Allele [NCIt concept]
- GRPR wt Allele [NCIt concept]
- HRH2 wt Allele [NCIt concept]
- HTR2A wt Allele [NCIt concept]
- HTR2C wt Allele [NCIt concept]
- ITPKB wt Allele [NCIt concept]
- ITPKC wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- LHCGR wt Allele [NCIt concept]
- MCOLN1 wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- NOS1 wt Allele [NCIt concept]
- NOS2 wt Allele [NCIt concept]
- NOS3 wt Allele [NCIt concept]
- NTSR1 wt Allele [NCIt concept]
- ORAI1 wt Allele [NCIt concept]
- P2RX2 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PLCD1 wt Allele [NCIt concept]
- PLCD3 wt Allele [NCIt concept]
- PLCE1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PLCG2 wt Allele [NCIt concept]
- PLN wt Allele [NCIt concept]
- PPIF wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- RYR1 wt Allele [NCIt concept]
- RYR2 wt Allele [NCIt concept]
- SLC25A4 wt Allele [NCIt concept]
- SLC25A5 wt Allele [NCIt concept]
- SLC25A6 wt Allele [NCIt concept]
- SLC8A1 wt Allele [NCIt concept]
- SPHK1 wt Allele [NCIt concept]
- SPHK2 wt Allele [NCIt concept]
- STIM1 wt Allele [NCIt concept]
- TACR1 wt Allele [NCIt concept]
- TACR3 wt Allele [NCIt concept]
- TBXA2R wt Allele [NCIt concept]
- TPCN2 wt Allele [NCIt concept]
- VDAC1 wt Allele [NCIt concept]
- VDAC2 wt Allele [NCIt concept]
- VDAC3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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