Kininogen-1 - CISMeF

Preferred Label : Kininogen-1;

NCIt synonyms : Alpha-2-Thiol Proteinase Inhibitor; Kininogen; Williams-Fitzgerald-Flaujeac Factor; High Molecular Weight Kininogen; Fitzgerald Factor; Kininogen 1; KNG1; HMWK;

NCIt definition : Kininogen-1 (644 aa, 72 kDa) is encoded by the human KNG1 gene. This protein is involved in the positive regulation of fibrinolysis.;

NCIt note : Kininogen-1 is cleaved into 6 biologically active peptides: kininogen-1 heavy chain, T-kinin (Ile-Ser-Bradykinin), bradykinin (Kallidin I), lysyl-bradykinin (Kallidin II), kininogen-1 light chain, and low molecular weight growth-promoting factor. (UniProt);

Details

Origin ID

C114390;

UMLS CUI

C3811710;

Automatic exact mappings (from CISMeF team)
- Kininogen [LOINC component]
- Kininogen (substance) [SNOMED CT concept]
- Kininogen 1 [OMIM gene]
- kininogen [MeSH concept]
- kininogen 1 [HGNC gene]
- kininogens [MeSH Descriptor]
- kininogens [MeSH concept]
Currated CISMeF NLP mapping
- High molecular weight kininogen (substance) [SNOMED CT concept]
- Kininogen HMW [LOINC component]
- high molecular weight kininogen [SNOMED Notion]
- kininogen, High-Molecular-Weight [MeSH concept]
- kininogen, high-molecular-weight [MeSH Descriptor]
OMIM relation
- Kininogen 1 [OMIM gene]
See also inter- (CISMeF)
- kininogen 1 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KNG1 protein, human [MeSH Supplementary Concept]
- KNG1 protein, human [MeSH concept]
Validated automatic mappings to BTNT
- KNG1 protein, human [MeSH Supplementary Concept]
- KNG1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- KNG1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Plasma [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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