" /> KNG1 wt Allele - CISMeF





Preferred Label : KNG1 wt Allele;

NCIt synonyms : KNG; HK; KNG wt Allele; Kininogen 1 wt Allele; BK; BDK;

NCIt definition : Human KNG1 wild-type allele is located in the vicinity of 3q27 and is approximately 27 kb in length. This allele, which encodes kininogen-1 protein, plays a role in the blood coagulation pathway. Mutation or deletion of the wild type allele can result in aberrations in blood coagulation, fibrin clot resolution and inflammatory responses.;

NCIt note : KNG1 encodes two proteins generated by alternative splicing called high molecular weight kininogen and low molecular weight kininogen, respectively. Proteolytic cleavage of high molecular weight kininogen by plasma kallikrein releases the vasoactive peptide bradykinin, and two-chain high molecular weight kininogen protein.;

GenBank Accession Number : NM_000893;

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29/04/2024


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