Plasma Kallikrein

Preferred Label : Plasma Kallikrein;

NCIt synonyms : Fletcher Factor; Kininogenin; Plasma Kallikrein Precursor; EC 3.4.21.34; Plasma Prekallikrein; KLKB1;

NCIt definition : Plasma kallikrein (638 aa, 71 kDa) is encoded by the human KLKB1 gene. This protein plays a role in the mediation of proteolysis.;

NCIt note : Plasma kallikrein must be cleaved by factor XIIa to be enzymatically active. Substrates for the active form of plasma kallikrein include factor XII and kininogen. (UniProt);

Details

Origin ID

C95409;

UMLS CUI

C5441858;

Automatic exact mappings (from CISMeF team)
- Kallikrein [LOINC component]
- Kallikrein (substance) [SNOMED CT concept]
- Kallikrein b, plasma, 1 [OMIM gene]
- Prekallikrein (Fletcher Factor) [LOINC component]
- Prekallikrein (substance) [SNOMED CT concept]
- kallikrein [SNOMED Notion]
- kallikrein B1 [ORDO Gene]
- kallikrein B1 [HGNC gene]
- prekallikrein [MeSH concept]
- prekallikrein [MeSH Descriptor]
Currated CISMeF NLP mapping
- plasma kallikrein [MeSH Descriptor]
- plasma kallikrein [MeSH concept]
OMIM relation
- Kallikrein b, plasma, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- plasma kallikrein [MeSH concept]
- plasma kallikrein [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- KLKB1 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kallikrein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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