Collagen Alpha-3(IV) Chain

Preferred Label : Collagen Alpha-3(IV) Chain;

NCIt synonyms : Goodpasture Antigen; Collagen, Type IV, Alpha 3 (Goodpasture Antigen); Collagen of Basement Membrane, Alpha-3 Chain; Collagen IV, Alpha-3 Polypeptide; COL4A3; Alpha 3 Type IV Collagen Precursor; COL4A3 Protein; Collagen IV Alpha-3; Collagen IV (Alpha 3);

NCIt definition : Collagen alpha-3(IV) chain (1670 aa, 162 kDa) is encoded by the human COL4A3 gene. This protein plays a role in the formation of basement membranes.;

NCIt note : The epitopes recognized by the autoantibodies in patients with Goodpasture syndrome are located within the NC1 hexamer of the type IV collagen network. (UniProt);

Details

Origin ID

C26002;

UMLS CUI

C1314894;

Currated CISMeF NLP mapping
- goodpasture antigen [MeSH concept]
OMIM relation
- Collagen, type iv, alpha-3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Col4A3 protein, human [MeSH concept]
gene_encodes_gene_product
- COL4A3 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Alveolus [NCIt concept]
gene_product_has_associated_anatomy
- Basement Membrane [NCIt concept]
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Extracellular Matrix Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myocardial Infarction Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Angiotensin-converting Enzyme 2 Pathway [NCIt concept]
- Bone Mineralization Regulation Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
- Platelet Amyloid Precursor Protein Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- Vitamin C in Brain Pathway [NCIt concept]
gene_product_is_physical_part_of
- Collagen IV [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alport Syndrome [NCIt concept]
- Goodpasture Syndrome [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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