Coagulation Factor XI

Preferred Label : Coagulation Factor XI;

NCIt synonyms : FXI; PTA; EC 3.4.21.27; Factor XI; F11; Plasma Thromboplastin Antecedent;

NCIt definition : Coagulation factor XI (625 aa, 70 kDa) is encoded by the human F11 gene. This protein is involved in the proteolytic activation of coagulation factor IX.;

NCIt note : Coagulation factor XI is a single chain zymogen that is cleaved after the arginine at amino acid residue 387 into two chains by activated coagulation factor XII. The active form of factor XI is composed of two heavy and two light chains held together by disulfide bonds.;

Details

Origin ID

C201572;

OMIM relation
- Coagulation factor XI [OMIM gene]
gene_encodes_gene_product
- Coagulation Factor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- F11 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Intrinsic Prothrombin Activation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

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