NCIt synonyms : Activated Protein C Cofactor; Proaccelerin, Labile Factor; Labile Factor; F5; Factor V;
NCIt definition : Coagulation factor V (2224 aa, 252 kDa) is encoded by the human F5 gene. This protein
plays a role in the coagulation cascade.;
NCIt note : Coagulation factor V has no activity until it is cleaved by thrombin into two chains,
called coagulation factor V heavy chain and coagulation factor V light chain. The
two chains are non-covalently bound in a complex, factor Va, which is a cofactor that
enhances the enzymatic activity of coagulation factor Xa.;