Pitx2 Transcription Regulation Pathway

Preferred Label : Pitx2 Transcription Regulation Pathway;

NCIt related terms : Multi-step Regulation of Transcription by Pitx2;

Alternative definition : BIOCARTA: Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated transcriptional control of proliferation in specific developmental cell types is crucial in multiple developmental settings. One of a family of three bicoid-related transcription factors, Pitx2 acts downstream of the extracellular signaling protein Wnt to drive proliferation of cells with specific developmental fates, including cells in the pituitary, cardiac outflow region, and muscle. Wnt binds to Frizzled, a G-protein coupled receptor, activating homologs of the Drosophila Disheveled protein. Activation of Frizzled and Disheveled inhibits the kinase GSK-3 beta, part of a protein complex in the absence of Wnt signaling, causing beta-catenin protein to accumulate in the cytoplasm. Beta-catenin is known to alter the function of transcription factors like TCF/Lef. One result of Wnt signaling is activation of the transcription factor Lef by beta-catenin, inducing Pitx2 expression. Wnt activation also changes Pitx2 from a repressor to an activator by causing transcriptional corepressors like histone deacetylase 1 (HDAC1) bound to Pitx2 to be exchanged for coactivators. With coactivators bound, Pitx2 activates transcription of genes that regulate the cell cycle, such as Cyclin D2. Different coactivators are recruited by Pitx2 and other transcription factors like Myc to the Cyclin D2 promoter, with CBP/p300 recruited first, followed by NLI/Ldb/CLIM, Tip60/TRRAP, and PBP coactivators. Many of these coactivators help to alter histone acetylation and chromatin structure as part of transcriptional activation. The activation of cell cycle genes by Pitx2 ultimately stimulates the proliferation of specific cell types with the confluence of tissue-specific gene expression, growth factor signaling and coactivator recruitment. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_pitx2Pathway;

Details

Origin ID

C39189;

UMLS CUI

C1514129;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Adenomatous Polyposis Coli Protein [NCIt concept]
- Axin-1 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Dickkopf-Related Protein 1 [NCIt concept]
- Frizzled-1 [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Histone Acetyltransferase KAT5 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- LIM Domain-Binding Protein 1 [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 6 [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mediator of RNA Polymerase II Transcription Subunit 1 [NCIt concept]
- Pituitary Homeobox 2 [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- Transformation/Transcription Domain-Associated Protein [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Wnt Inhibitory Factor 1 [NCIt concept]
pathway_has_gene_element
- APC wt Allele [NCIt concept]
- AXIN1 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- DKK1 wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- KAT5 wt Allele [NCIt concept]
- LDB1 wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- LRP6 wt Allele [NCIt concept]
- MED1 wt Allele [NCIt concept]
- PITX2 wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- TRRAP wt Allele [NCIt concept]
- WIF1 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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