Adenomatous Polyposis Coli Protein

Preferred Label : Adenomatous Polyposis Coli Protein;

NCIt synonyms : APC; APC Protein; Deleted In Polyposis 2.5; Adenomatosis Polyposis Coli Tumor Suppressor; Protein APC; Protein Phosphatase 1, Regulatory Subunit 46;

NCIt definition : Adenomatous polyposis coli protein (2843 aa, 312 kDa) is encoded by the human APC gene. This protein is involved in both tumor suppression and the inhibition of the Wnt signaling pathway.;

Details

Origin ID

C17687;

UMLS CUI

C2974530;

Currated CISMeF NLP mapping
- adenomatous polyposis coli protein [MeSH Descriptor]
- adenomatous polyposis coli protein [MeSH concept]
OMIM relation
- Apc regulator of wnt signaling pathway [OMIM gene]
See also inter- (CISMeF)
- Familial adenomatous polyposis 1 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- APC protein, human [MeSH concept]
- APC protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- APC Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
- Microtubule Associated Protein [NCIt concept]
- Tumor Suppressor Protein [NCIt concept]
gene_product_has_gene_product_variant
- APC NP_000029.2:p.D917Y [NCIt concept]
- APC NP_000029.2:p.I1307K [NCIt concept]
- APC Protein Variant [NCIt concept]
gene_product_is_element_in_pathway
- ALK Pathway [NCIt concept]
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Basal Cell Carcinoma Pathway [NCIt concept]
- Beta-Catenin Accumulation Pathway [NCIt concept]
- Canonical Wnt Signaling Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- Hippo Signaling Pathway [NCIt concept]
- Notch and Wnt Signaling Pathway [NCIt concept]
- Pitx2 Transcription Regulation Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- WNT Signaling Pathway BioCarta [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Familial Adenomatous Polyposis [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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