Hippo Signaling Pathway

Preferred Label : Hippo Signaling Pathway;

NCIt synonyms : Salvador-Warts-Hippo Pathway; Hippo Pathway;

NCIt definition : A signaling pathway that controls organ size through the regulation of cell proliferation and apoptosis. This pathway plays a role in progenitor cell self-renewal and expansion, and dysregulation may play a role in tumorigenesis.;

Alternative definition : KEGG: Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.;

KEGG ID : hsa04390;

Détails

Origin ID

C212948;

concept_is_in_subset
- Pediatric Oncology Biomarkers/Targets Associated with Other Relevant Evidence [NCIt concept]
has_gene_product_element
- 14-3-3 Protein Epsilon [NCIt concept]
- 14-3-3 Protein Theta [NCIt concept]
- 14-3-3 Protein Zeta/Delta [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Adenomatous Polyposis Coli Protein [NCIt concept]
- Adenomatous Polyposis Coli Protein 2 [NCIt concept]
- Alpha-Fetoprotein [NCIt concept]
- Amphiregulin [NCIt concept]
- Angiomotin [NCIt concept]
- Apoptosis-Stimulating of p53 Protein 2 [NCIt concept]
- Axin-1 [NCIt concept]
- Axin-2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]
- Bcl-2-Binding Component 3 [NCIt concept]
- Bone Morphogenetic Protein 2 [NCIt concept]
- Bone Morphogenetic Protein 4 [NCIt concept]
- Bone Morphogenetic Protein 5 [NCIt concept]
- Bone Morphogenetic Protein 6 [NCIt concept]
- Bone Morphogenetic Protein 7 [NCIt concept]
- Bone Morphogenetic Protein 8B [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-1A [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-1B [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-2 [NCIt concept]
- CCN Family Member 2 [NCIt concept]
- Cadherin-1 [NCIt concept]
- Casein Kinase I Isoform Delta [NCIt concept]
- Catenin Alpha-1 [NCIt concept]
- Catenin Alpha-2 [NCIt concept]
- Catenin Alpha-3 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-1 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-2 [NCIt concept]
- Disks Large Homolog 1 [NCIt concept]
- Disks Large Homolog 4 [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- Fibroblast Growth Factor 1 [NCIt concept]
- Frizzled-1 [NCIt concept]
- Frizzled-2 [NCIt concept]
- Frizzled-3 [NCIt concept]
- Frizzled-4 [NCIt concept]
- Frizzled-6 [NCIt concept]
- Frizzled-7 [NCIt concept]
- Frizzled-8 [NCIt concept]
- Frizzled-9 [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- G1/S-Specific Cyclin-D2 [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth/Differentiation Factor 5 [NCIt concept]
- Integrin Beta-2 [NCIt concept]
- LIM Domain-Containing Protein 1 [NCIt concept]
- LIM Domain-Containing Protein Ajuba [NCIt concept]
- Lethal(2) Giant Larvae Protein Homolog 1 [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- MOB Kinase Activator 1A [NCIt concept]
- MOB Kinase Activator 1B [NCIt concept]
- Merlin [NCIt concept]
- Mothers Against Decapentaplegic Homolog 1 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 7 [NCIt concept]
- Muellerian-Inhibiting Factor [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Partitioning Defective 3 Homolog [NCIt concept]
- Partitioning Defective 6 Homolog Alpha [NCIt concept]
- Plasminogen Activator Inhibitor 1 [NCIt concept]
- Protein Crumbs Homolog 2 [NCIt concept]
- Protein KIBRA [NCIt concept]
- Protein Kinase C Iota Type [NCIt concept]
- Protein PALS1 [NCIt concept]
- Protein Salvador Homolog 1 [NCIt concept]
- Protein Scribble Homolog [NCIt concept]
- Protein Wnt-10a [NCIt concept]
- Protein Wnt-10b [NCIt concept]
- Protein Wnt-11 [NCIt concept]
- Protein Wnt-16 [NCIt concept]
- Protein Wnt-2 [NCIt concept]
- Protein Wnt-2b [NCIt concept]
- Protein Wnt-4 [NCIt concept]
- Protein Wnt-5a [NCIt concept]
- Protein Wnt-5b [NCIt concept]
- Protein Wnt-6 [NCIt concept]
- Protein Wnt-7a [NCIt concept]
- Protein Wnt-9a [NCIt concept]
- Protein Wnt-9b [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- Proto-Oncogene Wnt-3 [NCIt concept]
- Ras Association Domain-Containing Protein 1 [NCIt concept]
- Segment Polarity Protein Dishevelled Homolog DVL-1 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase 3 [NCIt concept]
- Serine/Threonine-Protein Kinase 4 [NCIt concept]
- Serine/Threonine-Protein Kinase LATS1 [NCIt concept]
- Serine/Threonine-Protein Kinase LATS2 [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit [NCIt concept]
- TEAD Transcription Factor Family [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Transcription Factor SOX-2 [NCIt concept]
- Transcriptional Coactivator YAP1 [NCIt concept]
- Transcriptional Enhancer Factor TEF-3 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Protein p73 [NCIt concept]
- WW Domain-Containing Transcription Regulator Protein 1 [NCIt concept]
- Zinc Finger Protein GLI2 [NCIt concept]
- Zinc Finger Protein SNAI2 [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- AFP wt Allele [NCIt concept]
- AJUBA wt Allele [NCIt concept]
- AMH wt Allele [NCIt concept]
- AMOT wt Allele [NCIt concept]
- APC wt Allele [NCIt concept]
- APC2 wt Allele [NCIt concept]
- AREG wt Allele [NCIt concept]
- AXIN1 wt Allele [NCIt concept]
- AXIN2 wt Allele [NCIt concept]
- BBC3 wt Allele [NCIt concept]
- BIRC2 wt Allele [NCIt concept]
- BIRC3 wt Allele [NCIt concept]
- BIRC5 wt Allele [NCIt concept]
- BMP2 wt Allele [NCIt concept]
- BMP4 wt Allele [NCIt concept]
- BMP5 wt Allele [NCIt concept]
- BMP6 wt Allele [NCIt concept]
- BMP7 wt Allele [NCIt concept]
- BMP8B wt Allele [NCIt concept]
- BMPR1A wt Allele [NCIt concept]
- BMPR1B wt Allele [NCIt concept]
- BMPR2 wt Allele [NCIt concept]
- BTRC wt Allele [NCIt concept]
- CCN2 wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CCND2 wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CRB2 wt Allele [NCIt concept]
- CSNK1D wt Allele [NCIt concept]
- CTNNA1 wt Allele [NCIt concept]
- CTNNA2 wt Allele [NCIt concept]
- CTNNA3 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- DLG1 wt Allele [NCIt concept]
- DLG4 wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- FGF1 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- FZD2 wt Allele [NCIt concept]
- FZD3 wt Allele [NCIt concept]
- FZD4 wt Allele [NCIt concept]
- FZD6 wt Allele [NCIt concept]
- FZD7 wt Allele [NCIt concept]
- FZD8 wt Allele [NCIt concept]
- FZD9 wt Allele [NCIt concept]
- GDF5 wt Allele [NCIt concept]
- GLI2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- ID1 wt Allele [NCIt concept]
- ID2 wt Allele [NCIt concept]
- ITGB2 wt Allele [NCIt concept]
- LATS1 wt Allele [NCIt concept]
- LATS2 wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- LIMD1 wt Allele [NCIt concept]
- LLGL1 wt Allele [NCIt concept]
- MOB1A wt Allele [NCIt concept]
- MOB1B wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NF2 wt Allele [NCIt concept]
- PALS1 wt Allele [NCIt concept]
- PARD3 wt Allele [NCIt concept]
- PARD6A wt Allele [NCIt concept]
- PPP1CA wt Allele [NCIt concept]
- PPP1CB wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- PPP2R1B wt Allele [NCIt concept]
- PPP2R2A wt Allele [NCIt concept]
- PPP2R2B wt Allele [NCIt concept]
- PRKCI wt Allele [NCIt concept]
- RASSF1 wt Allele [NCIt concept]
- SAV1 wt Allele [NCIt concept]
- SCRIB wt Allele [NCIt concept]
- SERPINE1 wt Allele [NCIt concept]
- SMAD1 wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SMAD7 wt Allele [NCIt concept]
- SNAI2 wt Allele [NCIt concept]
- SOX2 wt Allele [NCIt concept]
- STK3 wt Allele [NCIt concept]
- STK4 wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TEAD4 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TP53BP2 wt Allele [NCIt concept]
- TP73 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]
- WNT10A wt Allele [NCIt concept]
- WNT10B wt Allele [NCIt concept]
- WNT11 wt Allele [NCIt concept]
- WNT16 wt Allele [NCIt concept]
- WNT2 wt Allele [NCIt concept]
- WNT2B wt Allele [NCIt concept]
- WNT3 wt Allele [NCIt concept]
- WNT4 wt Allele [NCIt concept]
- WNT5A wt Allele [NCIt concept]
- WNT5B wt Allele [NCIt concept]
- WNT6 wt Allele [NCIt concept]
- WNT7A wt Allele [NCIt concept]
- WNT9A wt Allele [NCIt concept]
- WNT9B wt Allele [NCIt concept]
- WWC1 wt Allele [NCIt concept]
- WWTR1 wt Allele [NCIt concept]
- YAP1 wt Allele [NCIt concept]
- YWHAE wt Allele [NCIt concept]
- YWHAQ wt Allele [NCIt concept]
- YWHAZ wt Allele [NCIt concept]

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