DLG4 wt Allele

Preferred Label : DLG4 wt Allele;

NCIt synonyms : Discs, Large Homolog 4 (Drosophila) wt Allele; PSD-95; PSD95; SAP90;

NCIt definition : Human DLG4 wild-type allele is located in the vicinity of 17p13.1 and is approximately 30 kb in length. This allele, which encodes discs large homolog 4 protein, plays a role in NMDA receptor signaling. Decreased DLG4 gene expression is associated with bipolar disorder and schizophrenia.;

NCIt note : The Dlg4 protein may interact with the Dlg2 protein to form a multimeric scaffold at postsynaptic sites to facilitate the convergence of ion channels, receptors and signaling proteins.;

GenBank Accession Number : NM_001365;

Details

Origin ID

C51057;

UMLS CUI

C1705335;

OMIM relation
- Discs large maguk scaffold protein 4 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 17: 7063754-7033933 [NCIt concept]
gene_in_chromosomal_location
- 17p13.1 [NCIt concept]
gene_is_element_in_pathway
- Nitric Oxide Signaling Pathway [NCIt concept]
- Synaptic Junction Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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