Preferred Label : Synaptic Junction Pathway;
NCIt related terms : Synaptic Proteins at the Synaptic Junction;
Alternative definition : BIOCARTA: The postsynaptic density (PSD) is a submembranous structure at the postsynaptic
membrane mainly at the excitatory synapses. The neurotransmitter receptors are assembled
and fixed at the PSD, and several molecules implicated in the synaptic plasticity
are also enriched. PSD-95/synapse-associated protein (SAP) 90 is involved in the molecular
organization of these components of the PSD and essential for learning and memory.
The common feature of these postsynaptic proteins is that they have PSD-95/Dlg/ZO-1
(PDZ) modular domains for protein-protein interaction. PDZ domains of these proteins
directly recognize the C termini of their target proteins and are believed to play
a central role in targeting and clustering of receptors to proper synaptic membranes.
(This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_PDZsPathway;
Origin ID : C39185;
UMLS CUI : C1515106;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
