Neural Cell Adhesion Molecule 1

Preferred Label : Neural Cell Adhesion Molecule 1;

NCIt synonyms : CD56 Antigen; NCAM1; NKH-1; NCAM; Antigen MSK39 Identified By Monoclonal Antibody 5.1H11; NCAM-1; N-CAM-1; Neural Cell Adhesion Molecule;

NCIt related terms : CD56;

NCIt definition : Neural cell adhesion molecule 1 (761 aa, 84 kDa) is encoded by the human NCAM1 gene. This protein is involved in the mediation of neuron-neuron adhesion.;

NCIt note : Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions. NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis. Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation. NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding. The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation. Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.;

Details

Origin ID

C25276;

UMLS CUI

C4281806;

Currated CISMeF NLP mapping
- CD56 Antigen [MeSH Descriptor]
- CD56 Antigen [MeSH concept]
- Neural cell adhesion molecule [FMA entity]
- neural cell adhesion molecules [MeSH Descriptor]
- neural cell adhesion molecules [MeSH concept]
OMIM relation
- Cell adhesion molecule, neural, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- NCAM1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Natural Killer Cell [NCIt concept]
- Neuron [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Synaptic Junction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-GD2/Anti-CD56 4SCAR-expressing Bispecific T-cells [NCIt concept]
- Lorvotuzumab Mertansine [NCIt concept]

Keyword's position in hierarchy(ies) :

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