Disks Large Homolog 4

Preferred Label : Disks Large Homolog 4;

NCIt synonyms : Presynaptic Density Protein 95; SAP90; PSD-95; Postsynaptic Density-95; Synapse-Associated Protein 90; SAP-90; Presynaptic Density Protein-95;

NCIt definition : Disks large homolog 4 (724 aa, 80 kDa) is encoded by the human DLG4 gene. This protein is involved in synaptic signal transmission.;

NCIt note : Disks large homolog 4 contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. This protein also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.;

Details

Origin ID

C29570;

UMLS CUI

C0900627;

OMIM relation
- Discs large maguk scaffold protein 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- DLG4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- PDZ Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Nitric Oxide Signaling Pathway [NCIt concept]
- Synaptic Junction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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