PPP1CA wt Allele

Preferred Label : PPP1CA wt Allele;

NCIt synonyms : PPP1A; Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform wt Allele;

NCIt definition : Human PPP1CA wild-type allele is located within 11q13 and is approximately 4 kb in length. This allele, which encodes serine/threonine-protein phosphatase PP1-alpha catalytic subunit protein, plays a role in the dephosphorylation of phosphoproteins and exit from the mitotic stage of the cell cycle. The PPP1CA gene is associated with susceptibility to cancers such as type I multiple endocrine neoplasia.;

GenBank Accession Number : NM_002708;

Details

Origin ID

C49421;

UMLS CUI

C1706174;

OMIM relation
- Protein phosphatase 1, catalytic subunit, alpha isoform [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 11q13 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- BMP Receptor Signaling Pathway [NCIt concept]
- CK1/CDK5 Regulation Pathway [NCIt concept]
- Centrosome Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Division Process [NCIt concept]
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Protein Synthesis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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