Insulin/Insulin Receptor Signaling Pathway

Preferred Label : Insulin/Insulin Receptor Signaling Pathway;

NCIt related terms : Insulin signaling pathway;

Alternative definition : KEGG: Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.;

KEGG ID : hsa04910;

Details

Origin ID

C91489;

UMLS CUI

C2984300;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- 40S Ribosomal Protein S6 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Subunit Gamma-2 [NCIt concept]
- Acetyl-CoA Carboxylase 1 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Calmodulin [NCIt concept]
- Cdc42-Interacting Protein 4 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E Type 2 [NCIt concept]
- Exocyst Complex Component 7 [NCIt concept]
- Fatty Acid Synthase [NCIt concept]
- Forkhead Box Protein O1 [NCIt concept]
- Fructose-1,6-Bisphosphatase 1 [NCIt concept]
- GTP-Binding Protein Rheb [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glucose-6-Phosphatase 3 [NCIt concept]
- Glycogen Phosphorylase, Brain Form [NCIt concept]
- Glycogen Phosphorylase, Liver Form [NCIt concept]
- Glycogen Phosphorylase, Muscle Form [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Hamartin [NCIt concept]
- Hexokinase-1 [NCIt concept]
- Hexokinase-2 [NCIt concept]
- Hexokinase-4 [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin Receptor Substrate 4 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Iota Type [NCIt concept]
- Pyruvate Kinase PKLR [NCIt concept]
- Pyruvate Kinase PKLR Isoform L-Type [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- Ryanodine Receptor 2 [NCIt concept]
- SH2B Adapter Protein 2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Sterol Regulatory Element-Binding Protein 1 [NCIt concept]
- Suppressor of Cytokine Signaling 1 [NCIt concept]
- Suppressor of Cytokine Signaling 2 [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- Tuberin [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 1 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]
pathway_has_gene_element
- ACACA wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- EIF4E wt Allele [NCIt concept]
- EIF4E2 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- EXOC7 wt Allele [NCIt concept]
- FASN wt Allele [NCIt concept]
- FBP1 wt Allele [NCIt concept]
- FOXO1 wt Allele [NCIt concept]
- G6PC3 wt Allele [NCIt concept]
- GCK wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HK1 wt Allele [NCIt concept]
- HK2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- INPP5D wt Allele [NCIt concept]
- INPPL1 wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- IRS4 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PKLR wt Allele [NCIt concept]
- PPARGC1A wt Allele [NCIt concept]
- PPP1CA wt Allele [NCIt concept]
- PPP1CB wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKAG2 wt Allele [NCIt concept]
- PRKAR1A wt Allele [NCIt concept]
- PRKAR2A wt Allele [NCIt concept]
- PRKCI wt Allele [NCIt concept]
- PTPN1 wt Allele [NCIt concept]
- PYGB wt Allele [NCIt concept]
- PYGL wt Allele [NCIt concept]
- PYGM wt Allele [NCIt concept]
- RAPGEF1 wt Allele [NCIt concept]
- RHEB wt Allele [NCIt concept]
- RPS6 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- RYR2 wt Allele [NCIt concept]
- SH2B2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SOCS1 wt Allele [NCIt concept]
- SOCS2 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SREBF1 wt Allele [NCIt concept]
- TRIP10 wt Allele [NCIt concept]
- TSC1 wt Allele [NCIt concept]
- TSC2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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