NCIt synonyms : OA-519; Fatty Acid Synthase wt Allele; FAS; MGC15706; MGC14367; Short Chain Dehydrogenase/Reductase Family 27X, Member 1 Gene; SDR27X1;
NCIt definition : Human FASN wild-type allele is located within 17q25 and is approximately 20 kb in
length. This allele, which encodes fatty acid synthase protein, is involved in the
biosynthesis of long-chain fatty acids. The FASN gene is overexpressed in many epithelial
cancers and is associated with poor prognosis.;
NCIt note : Inhibition of FASN gene expression in cancer cells negatively regulates growth and
induces apoptosis.;