" /> HK2 wt Allele - CISMeF





Preferred Label : HK2 wt Allele;

NCIt synonyms : Hexokinase 2 wt Allele; HKII; HXK2;

NCIt definition : Human HK2 wild-type allele is located within 2p13 and is approximately 61 kb in length. This allele, which encodes hexokinase-2 protein, plays a role in the phosphorylation of glucose to produce glucose-6-phosphate.;

NCIt note : The HK2 gene is expressed in insulin-responsive tissues such as skeletal muscle. Up-regulation of HK2 gene expression may contribute to the increased rate of glycolysis seen in rapidly growing cancer cells. The promoter region of the HK2 gene isolated from hepatoma cells displays consensus motifs for hypoxia-inducible factor (HIF-1). Under hypoxic conditions, the HK2 gene promoter is activated, and this effect is dramatically increased in the presence of glucose. Induction of HK2 gene expression in hepatoma cells under hypoxic conditions may confer a growth and survival advantage over their normal parental cells of origin.;

GenBank Accession Number : NM_000189;

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20/05/2024


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