Type II Diabetes Mellitus Pathway

Preferred Label : Type II Diabetes Mellitus Pathway;

NCIt related terms : Type II diabetes mellitus;

Alternative definition : KEGG: Insulin resistance is strongly associated with type II diabetes. Diabetogenic factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.;

KEGG ID : hsa04930;

Details

Origin ID

C91490;

UMLS CUI

C2984301;

Automatic exact mappings (from CISMeF team)
- Diabetes mellitus Type II [HPO term]
- Diabetes mellitus type 2 (disorder) [SNOMED CT concept]
- Maturity onset diabetes [MedDRA LLT]
- Type 2 diabetes mellitus [OMIM Phenotype]
- Type 2 diabetes mellitus [ICD-11 Category]
- Type II diabetes mellitus [MedDRA LLT]
- Type II diabetes mellitus [HPO term]
- diabetes mellitus type ii [SNOMED Notion]
- diabetes mellitus, type 2 [MeSH Descriptor]
- type 2 diabetes mellitus [DO Concept]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- ATP-Binding Cassette Sub-Family C Member 8 [NCIt concept]
- ATP-Sensitive Inward Rectifier Potassium Channel 11 [NCIt concept]
- Adiponectin [NCIt concept]
- Hepatocyte Nuclear Factor 1-Beta [NCIt concept]
- Hexokinase-1 [NCIt concept]
- Hexokinase-2 [NCIt concept]
- Hexokinase-4 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin Receptor Substrate 4 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Pancreas/Duodenum Homeobox Protein 1 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Protein Kinase C Epsilon Type [NCIt concept]
- Pyruvate Kinase PKLR [NCIt concept]
- Pyruvate Kinase PKLR Isoform L-Type [NCIt concept]
- Pyruvate Kinase PKM [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Solute Carrier Family 2, Facilitated Glucose Transporter Member 2 [NCIt concept]
- Suppressor of Cytokine Signaling 1 [NCIt concept]
- Suppressor of Cytokine Signaling 2 [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- Transcription Factor MafA [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A [NCIt concept]
- Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G [NCIt concept]
- Zinc Transporter 8 [NCIt concept]
pathway_has_gene_element
- ABCC8 wt Allele [NCIt concept]
- ADIPOQ wt Allele [NCIt concept]
- CACNA1A wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1G wt Allele [NCIt concept]
- GCK wt Allele [NCIt concept]
- HK1 wt Allele [NCIt concept]
- HK2 wt Allele [NCIt concept]
- HNF1B wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- IRS4 wt Allele [NCIt concept]
- KCNJ11 wt Allele [NCIt concept]
- MAFA wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- PDX1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PKLR wt Allele [NCIt concept]
- PKM wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PRKCE wt Allele [NCIt concept]
- SLC2A2 wt Allele [NCIt concept]
- SLC30A8 wt Allele [NCIt concept]
- SOCS1 wt Allele [NCIt concept]
- SOCS2 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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