Mitogen-Activated Protein Kinase 8

Preferred Label : Mitogen-Activated Protein Kinase 8;

NCIt synonyms : SAPK/JNK; Stress-Activated Protein Kinase 1; MAPK8; SAPK1; JN Kinase; SAPK1/JNK; JNK1 Protein; c-JUN N-Terminal Kinase; Stress-Activated Protein Kinase JNK1; MAP Kinase 8; SAPK1c; EC 2.7.11.24; MAPK 8; Stress-Activated Protein Kinase 1c; MAP-Kinase-8;

NCIt definition : Mitogen-activated protein kinase 8 (427 aa, 48 kDa) is encoded by the human MAPK8 gene. This protein plays a role in serine/threonine phosphorylation, apoptosis and toll-like receptor signaling.;

NCIt note : Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells.;

Details

Origin ID

C17780;

UMLS CUI

C5441984;

OMIM relation
- Mitogen-activated protein kinase 8 [OMIM gene]
See also inter- (CISMeF)
- Mitogen-Activated protein kinase 8 [LOINC component]
- Mitogen-activated protein kinase 8 [OMIM gene]
- mitogen-activated protein kinase 8 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Mitogen-Activated protein kinase 8 [MeSH concept]
- Mitogen-Activated protein kinase 8 [MeSH Descriptor]
Validated automatic mappings to NTBT
- Mitogen-Activated protein kinase 8 [MeSH Descriptor]
- Mitogen-Activated protein kinase 8 [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP Kinase Gene [NCIt concept]
- MAPK8 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- 4-1BB-Dependent Immune Response Pathway [NCIt concept]
- ATM Signaling Pathway [NCIt concept]
- Adipocytokine Signaling Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- B-Cell Immune Response Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Bone Remodeling Pathway [NCIt concept]
- CCR5 Signaling Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAP Kinase Regulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- T-Cell Proliferation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- JNK1 Inhibitor BMS-986360 [NCIt concept]

Keyword's position in hierarchy(ies) :

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