" /> MTOR wt Allele - CISMeF





Preferred Label : MTOR wt Allele;

NCIt synonyms : RAFT1; FRAP2; RAPT1; Rapamycin and FKBP12 Target 1 Gene; FRAP; FK506 Binding Protein 12-Rapamycin Associated Protein 1 Gene; FRAP1; Mechanistic Target of Rapamycin wt Allele; FLJ44809; dJ576K7.1 (FK506 Binding Protein 12-Rapamycin Associated Protein 1) Gene; Mechanistic Target of Rapamycin (Serine/Threonine Kinase) Gene; Mammalian Target of Rapamycin Gene; FRAP1 wt Allele;

NCIt definition : Human MTOR wild-type allele is located in the vicinity of 1p36.2 and is approximately 156 kb in length. This allele, which encodes serine/threonine-protein kinase mTOR protein, is involved in translational control and the regulation of ribosome biogenesis. The MTOR gene is associated with polycystic kidney disease.;

NCIt note : The FRAP1 gene is regulated both by growth factors, hormones and nutrients. Its product, FKBP12-rapamycin complex-associated protein, is activated in polycystic kidneys, which leads to the production of kidney cysts. This protein is inhibited by the drug rapamycin.;

GenBank Accession Number : NM_004958;

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12/05/2024


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