mTOR Signaling Pathway KEGG

Preferred Label : mTOR Signaling Pathway KEGG;

NCIt related terms : mTOR Signaling Pathway;

NCIt definition : A set of complex signal transduction pathways described by the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database, where each is dependent on the protein kinase activity of serine/threonine-protein kinase mTOR. This kinase is part of 2 structurally and functionally distinct signaling complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2, respectively), which together regulate cellular metabolism, growth and survival in response to hormones, growth factors, nutrients and stress signals.;

KEGG ID : hsa04150;

Details

Origin ID

C91431;

UMLS CUI

C2984244;

Semantic type(s)
- Molecular Function [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- 40S Ribosomal Protein S6 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 [NCIt concept]
- Arylamine N-Acetyltransferase 1 [NCIt concept]
- Eukaryotic Translation Initiation Factor 4B [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E Type 2 [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- GATOR Complex Protein DEPDC5 [NCIt concept]
- GATOR Complex Protein NPRL2 [NCIt concept]
- GATOR Complex Protein NPRL3 [NCIt concept]
- GTP-Binding Protein Rheb [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 10 [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Hamartin [NCIt concept]
- Hypoxia-Inducible Factor 1-Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidate Phosphatase LPIN2 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Wnt-10a [NCIt concept]
- Protein Wnt-10b [NCIt concept]
- Protein Wnt-11 [NCIt concept]
- Protein Wnt-2 [NCIt concept]
- Protein Wnt-2b [NCIt concept]
- Protein Wnt-4 [NCIt concept]
- Protein Wnt-5a [NCIt concept]
- Protein Wnt-6 [NCIt concept]
- Protein Wnt-9a [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- Proto-Oncogene Wnt-3 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS-Related GTP-Binding Protein A [NCIt concept]
- Ras-Related GTP-Binding Protein C [NCIt concept]
- Ras-Related GTP-Binding Protein D [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-3 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase STK11 [NCIt concept]
- Serine/Threonine-Protein Kinase ULK1 [NCIt concept]
- Serine/Threonine-Protein Kinase ULK2 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Sodium-Coupled Neutral Amino Acid Transporter 9 [NCIt concept]
- TBC1 Domain Family Member 7 [NCIt concept]
- Target of Rapamycin Complex Subunit LST8 [NCIt concept]
- Tuberin [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- V-Type Proton ATPase Subunit B, Brain Isoform [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ATP6V1B2 wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- DEPDC5 wt Allele [NCIt concept]
- EIF4B wt Allele [NCIt concept]
- EIF4E wt Allele [NCIt concept]
- EIF4E2 wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- GRB10 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HIF1A wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LPIN2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MLST8 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- NAT1 wt Allele [NCIt concept]
- NPRL2 wt Allele [NCIt concept]
- NPRL3 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PRKAA1 wt Allele [NCIt concept]
- PRKAA2 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- RHEB wt Allele [NCIt concept]
- RPS6 wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA3 wt Allele [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- RRAGA wt Allele [NCIt concept]
- RRAGC wt Allele [NCIt concept]
- RRAGD wt Allele [NCIt concept]
- SLC38A9 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- STK11 wt Allele [NCIt concept]
- TBC1D7 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TSC1 wt Allele [NCIt concept]
- TSC2 wt Allele [NCIt concept]
- ULK1 wt Allele [NCIt concept]
- ULK2 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]
- WNT10A wt Allele [NCIt concept]
- WNT10B wt Allele [NCIt concept]
- WNT11 wt Allele [NCIt concept]
- WNT2 wt Allele [NCIt concept]
- WNT2B wt Allele [NCIt concept]
- WNT3 wt Allele [NCIt concept]
- WNT4 wt Allele [NCIt concept]
- WNT5A wt Allele [NCIt concept]
- WNT9A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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