Prostate Cancer Pathway

Preferred Label : Prostate Cancer Pathway;

NCIt related terms : Prostate cancer;

Alternative definition : KEGG: The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation.;

KEGG ID : hsa05215;

Details

Origin ID

C91517;

UMLS CUI

C2984325;

Automatic exact mappings (from CISMeF team)
- Cancer of prostate [MedDRA LLT]
- Carcinoma of prostate (disorder) [SNOMED CT concept]
- Malignant tumor of prostate (disorder) [SNOMED CT concept]
- Prostate cancer [MedDRA Preferred Term]
- Prostate cancer [PASCAL descriptor]
- Prostate cancer [OMIM Phenotype]
- Prostate cancer [HPO term]
- Prostate cancer [HPMULTI term]
- Prostatic cancer [MedDRA LLT]
- prostate cancer [DO Concept]
- prostate cancer [Radlex concept]
- prostate cancer [MeSH concept]
- prostate cancer [MedlinePlus Topic]
- prostate carcinoma [DO Concept]
- prostatic neoplasms [MeSH Descriptor]
See also inter- (CISMeF)
- Malignant neoplasms of prostate [ICD-11 Category]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Androgen Receptor [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Caspase-9 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 5 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- Endoplasmin [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
- Forkhead Box Protein O1 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glutathione S-Transferase P [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Heat Shock Protein HSP 90-Alpha [NCIt concept]
- Heat Shock Protein HSP 90-Beta [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Homeobox Protein Nkx-3.1 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Insulin Receptor-Related Receptor [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Platelet-Derived Growth Factor C [NCIt concept]
- Platelet-Derived Growth Factor D [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Platelet-Derived Growth Factor Subunit B [NCIt concept]
- Prostate-Specific Antigen [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Alpha [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- AR wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- CREB3 wt Allele [NCIt concept]
- CREB3L1 wt Allele [NCIt concept]
- CREB3L2 wt Allele [NCIt concept]
- CREB3L3 wt Allele [NCIt concept]
- CREB3L4 wt Allele [NCIt concept]
- CREB5 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- FGFR1 wt Allele [NCIt concept]
- FGFR2 wt Allele [NCIt concept]
- FOXO1 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- GSTP1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- HSP90AA1 wt Allele [NCIt concept]
- HSP90AB1 wt Allele [NCIt concept]
- HSP90B1 wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- INSRR wt Allele [NCIt concept]
- KLK3 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFB wt Allele [NCIt concept]
- PDGFC wt Allele [NCIt concept]
- PDGFD wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TGFA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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