eIF4 Regulation Pathway

Preferred Label : eIF4 Regulation Pathway;

NCIt related terms : Regulation of eIF4e and p70 S6 Kinase; Regulation of eif-4e and p70s6 Kinase;

Alternative definition : BIOCARTA: eIF-4F and p70 S6 kinase play critical roles in translational regulation. eIF-4F is a complex whose functions include the recognition of the mRNA 5' cap structure (eIF-4E), delivery of an RNA helicase to the 5' region (eIF-4A), bridging of the mRNA and the ribosome (eIF-4G), and circularization of the mRNA via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kinase by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kinase. FRAP/mTOR, together with an unidentified kinase, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kinase stimulates the translation of mRNAs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_eif4Pathway;

Details

Origin ID

C39062;

UMLS CUI

C1515620;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Arylamine N-Acetyltransferase 1 [NCIt concept]
- Eukaryotic Initiation Factor 4A-II [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- Growth Hormone Receptor [NCIt concept]
- Insulin Receptor Substrate 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Polyadenylate-Binding Protein 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- EIF4A2 wt Allele [NCIt concept]
- EIF4E wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- GHR wt Allele [NCIt concept]
- IRS1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MKNK1 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- NAT1 wt Allele [NCIt concept]
- PABPC1 wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTEN wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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