Preferred Label : MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1;
NCIt synonyms : Mnk1; MAP Kinase Signal-Integrating Kinase 1; EC 2.7.11.1; MKNK1; MAP Kinase Interacting Kinase 1; MAP Kinase-Interacting Serine/Threonine Kinase 1; MAP-Kinase Interacting Kinase-1;
NCIt definition : MAP kinase-interacting serine/threonine-protein kinase 1 (465 aa, 51 kDa) is encoded
by the human MKNK1 gene. This protein may play a role in translation initiation.;
NCIt note : MAP Kinase Interacting Kinase 1 isoforms contain a typical Ser/Thr kinase domain,
an N-terminal putative NLS, and share homology with MAPKAPK2, MAPKAPK3, and p90(RSK).
Strongly interacting with, and phosphorylated/activated (via C-terminal region) by,
dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many
extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal
regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing
affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor
p97 C- terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation.;
Origin ID : C33991;
UMLS CUI : C0539636;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
