Insulin Receptor Substrate 1

Preferred Label : Insulin Receptor Substrate 1;

NCIt synonyms : IRS1; IRS-1; Insulin Receptor Substrate-1;

NCIt definition : Insulin receptor substrate 1 (1242 aa, 132 kDa) is encoded by the human IRS1 gene. This protein is involved in insulin-mediated signaling.;

NCIt note : The protein IRS1 acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797);

Details

Origin ID

C28474;

UMLS CUI

C0121830;

Currated CISMeF NLP mapping
- Insulin receptor substrate 1 [OMIM Phenotype]
- insulin receptor Substrate-1 protein [MeSH concept]
OMIM relation
- Insulin receptor substrate 1 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRS1 protein, human [MeSH Supplementary Concept]
- IRS1 protein, human [MeSH concept]
- insulin receptor Substrate-1 protein [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- IRS1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_is_element_in_pathway
- Growth Hormone Signaling Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL4 Signaling Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
is_target
- IRS1/IRS2/STAT3 Inhibitor NT219 [NCIt concept]

Keyword's position in hierarchy(ies) :

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