Preferred Label : IRS1/IRS2/STAT3 Inhibitor NT219;
NCIt related terms : NT-219;
NCIt definition : An inhibitor of signal transducer and activator of transcription 3 (STAT3) and insulin
receptor substrate 1 (IRS1) and 2 (IRS2), with potential antineoplastic activity.
Upon administration, the IRS1/IRS2/STAT3 inhibitor NT219 specifically targets and
binds to IRS1/2 and STAT3. Inhibiting IRS1/2 prevents IRS1/2-mediated signaling pathways
and other tumor survival pathways. Inhibiting STAT3 prevents nuclear translocation
of STAT3 and the STAT3-mediated regulation of oncogenes expression. This causes tumor
cell apoptosis and inhibits tumor cell proliferation. IRS1/2 and STAT3, oncogenic
drivers that are upregulated in a variety of human cancers, play key roles in uncontrolled
tumor cell proliferation and tumor resistance.;
UNII : K1WT1A1UP5;
CAS number : 1198078-60-2;
Molecule name : NT 219; NT-219;
NCI Metathesaurus CUI : CL1647825;
Origin ID : C178343;
UMLS CUI : C5554968;
Semantic type(s)
- concept_is_in_subset
- has_target
