Insulin Receptor Substrate 2

Preferred Label : Insulin Receptor Substrate 2;

NCIt synonyms : IRS2; IRS-2; Insulin Receptor Substrate-2;

NCIt definition : Insulin receptor substrate 2 (1338 aa, 137 kDa) is encoded by the human IRS2 gene. This protein is involved in insulin-dependent signal transduction.;

NCIt note : Tyrosine-phosphorylated IRS2 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS2 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin-4 receptor (IL4R) -associated kinase in response to IL4 treatment. (LocusLink);

Details

Origin ID

C28475;

UMLS CUI

C1334191;

OMIM relation
- Insulin receptor substrate 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRS2 protein, human [MeSH Supplementary Concept]
- IRS2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- IRS2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
is_target
- IRS1/IRS2/STAT3 Inhibitor NT219 [NCIt concept]

Keyword's position in hierarchy(ies) :

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