Insulin Signaling Pathway

Preferred Label : Insulin Signaling Pathway;

Alternative definition : BIOCARTA: The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the insulin receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_insulinPathway;

Details

Origin ID

C39130;

UMLS CUI

C1512804;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 [NCIt concept]
- 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Casein Kinase II Subunit Alpha [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- Forkhead Box Protein C2 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Insulin [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin Receptor Substrate 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Solute Carrier Family 2, Facilitated Glucose Transporter Member 2 [NCIt concept]
- Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- CSNK2A1 wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- FOXC2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- INS wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- IRS1 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MKNK1 wt Allele [NCIt concept]
- MKNK2 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PRKAA1 wt Allele [NCIt concept]
- PRKAA2 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SLC2A2 wt Allele [NCIt concept]
- SLC2A4 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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