Tyrosine-Protein Phosphatase Non-Receptor Type 11

Preferred Label : Tyrosine-Protein Phosphatase Non-Receptor Type 11;

NCIt synonyms : SHP2 Phosphatase; PTPN11; Protein Tyrosine Phosphatase 2C; Protein-Tyrosine Phosphatase 1D; PTP-2C; EC 3.1.3.48; SH-PTP3; Shp2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; SH-PTP2; SHP-2; PTP-1D; Non-Receptor Type 11 Protein Tyrosine Phosphatase; Tyrosine Phosphatase SHP2;

NCIt definition : Tyrosine-protein phosphatase non-receptor type 11 (597 aa, 68 kDa) is encoded by the human PTPN11 gene. This protein is involved in hormone-mediated signaling, cell adhesion and dephosphorylation of proteins.;

NCIt note : Protein_Plays_Role_In_Biological_Process: Cell Morphogenesis;

Details

Origin ID

C18030;

UMLS CUI

C1566685;

Currated CISMeF NLP mapping
- protein tyrosine phosphatase, Non-Receptor type 11 [MeSH Descriptor]
- protein tyrosine phosphatase, Non-Receptor type 11 [MeSH concept]
OMIM relation
- Protein-tyrosine phosphatase, nonreceptor-type, 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPN11 protein, human [MeSH concept]
- PTPN11 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTPN11 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_gene_product_variant
- PTPN11 NP_002825.3:p.G503A [NCIt concept]
- PTPN11 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Erythropoietin Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1 Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- N-Cadherin Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- VEGFR1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Dephosphorylation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Metabolic Control [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcription [NCIt concept]
is_target
- Batoprotafib [NCIt concept]
- SHP2 Inhibitor BBP-398 [NCIt concept]
- SHP2 Inhibitor ERAS-601 [NCIt concept]
- SHP2 Inhibitor ET0038 [NCIt concept]
- SHP2 Inhibitor HBI-2376 [NCIt concept]
- SHP2 Inhibitor HS-10381 [NCIt concept]
- SHP2 Inhibitor JAB-3312 [NCIt concept]
- SHP2 Inhibitor PF-07284892 [NCIt concept]
- SHP2 Inhibitor RLY-1971 [NCIt concept]
- SHP2 Inhibitor SH3809 [NCIt concept]
- Vociprotafib [NCIt concept]

Keyword's position in hierarchy(ies) :

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